Regulatory mechanisms of B cell responses and the implication in B cell-related diseases

Table 1 miRNAs in B cell malignancy and autoimmune diseases

miRNA	Biological function	Target genes	Disease type	References
miR-155	Promote TNFα-dependent proliferation	SHIP1	DCBCL	[60]
miR-155	Promote proliferation and inhibits apoptosis	PI3K/AKT pathway	DCBCL	[61]
miR-101	Inhibit proliferation and facilitate apoptosis	MEK1	DCBCL	[65]
miR-125b	Inhibit apoptosis	p53	MM	[74, 75]
miR-19b/20a	Promote proliferation, migration, and inhibit apoptosis	PTEN	MM	[78]
miR-34a	Regulate cell cycle progression, cellular senescence and apoptosis	SIRT1	MM	[77]
miR-34a	Reduce tumor growth	Foxp1	DLBCL	[49]
miR-9	Inhibit apoptosis	TRIM56/NF-κB pathway	MM	[79]
miR-7	Promote B cell hyperresponsiveness	PTEN	SLE	[83]
miR-17-5p	Inhibit IFN-inducible gene	c-MYC, and E2F1	SLE	[84]

ISSN: 1423-0127