Regulatory mechanisms of B cell responses and the implication in B cell-related diseases

Table 2 Epigenetic controls in B cell malignancy and autoimmune diseases

Histone Modifier	Biological function	Target genes (direct or indirect)	Disease type	References
EZH2	Promote growth	CDKN1A	DCBCL	[120]
EZH2	Retrain plasma cell differentiation	PRDM1 and IRF4	Non-Hodgkin lymphomas	[103]
KDM4A	Promote B cell activation and differentiation	WDR5	SLE	[99]
KDM4C	Promote B cell activation and differentiation	WDR5	SLE	[99]
LSD1	Promote differentiation	Blimp-1 targets, such as CIITA and c-MYC	MM	[117]
MMSET	Promote growth	c-MYC	MM	[135]
KDM6A	Promote oncogenesis	BCL-6, IRF4 and c-MYC	MM	[140]
KDM3A	Promote homing of MM cells	KLF2, and IRF4	MM	[141]
WDR5	Inhibit proliferation	CDKN2, and CDKN3	SLE	[99]
CREBBP	Regulate GC reaction and proliferation	BCL-6 targets, such as BCL-2 and PRDM1	FL and DCBCL	[128]
KMT2D	Repress lymphoma development	Genes in CD40, JAK-STAT, TLR and BCR pathways	FL and DCBCL	[123]
DNMT1	Promote BCR signaling	CD5, and CD5-E1B	SLE	[146]

ISSN: 1423-0127