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Fig. 3 | Journal of Biomedical Science

Fig. 3

From: MFG-E8 mediates arterial aging by promoting the proinflammatory phenotype of vascular smooth muscle cells

Fig. 3

Treatment of aged CCAs with MFG-E8 increases ICAM-1 expression in the vascular wall. ac Photographs depicting representative immunostaining of ICAM-1 in the left carotid artery from young (a) and aged (b) mice subjected to ligation injury 21 days after surgery. (c) rMFG-E8 (2 μg/mL) was delivered using Pluronic gel into the CCAs of aged mice immediately after complete ligation of the vessels; bar, 100 μm. d Quantitative analysis of immunostaining intensities of ICAM-1 in the intimal–medial area 21 days after ligation (young ligated: n = 3; aged ligated: n = 6; aged ligated + MFG-E8: n = 4). Data are presented as mean ± SEM. *P < 0.05 and **** P < 0.0001; one-way was analysis of variance followed by Tukey’s multiple comparison test

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