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Fig. 8 | Journal of Biomedical Science

Fig. 8

From: MFG-E8 mediates arterial aging by promoting the proinflammatory phenotype of vascular smooth muscle cells

Fig. 8

Exogenous MFG-E8 into carotid arteries dose not significantly increase ligation-induced vascular remodeling in aged mice. ac Representative images displaying the cross-sectional areas of sham-operated (a) and ligated (b) carotid arteries of aged mice 21 days after ligation or sham operation. rMFG-E8 (2 μg/mL) was delivered using Pluronic gel into the CCAs of aged mice immediately after complete ligation of the vessels (c). Verhoeff–van Gieson staining was performed on all sections; bar, 100 μm. dh Morphometric analyses of the areas of intima+media (d), intima (e), media (f), and lumen (h) and the I/M ratio (g) 21 days after ligation (n = 5–8 for each experimental group). Data are presented as mean ± SEM. *P < 0.05; one-way was analysis of variance followed by Tukey’s multiple comparison test

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