From: Natural outer membrane permeabilizers boost antibiotic action against irradiated resistant bacteria
Isolate No./ Species of microorganism | Radiation | Half of inhibition zone (mm) in absence AMC / adjacent to AMC disk (DDST) Mean ± SD (SE) | Half of inhibition zone (mm) in absence TZP/adjacent to TZP disk (MDDT) Mean ± SD (SE) | ||||||
---|---|---|---|---|---|---|---|---|---|
AMC | CTX | CAZ | FEP | ATM | TZP | CAZ | FEP | ||
2/ Escherichia coli | Before | 5.5 ± 0.5(0.3) | 3 ± 0.5(0.3) /7 ± 0.5(0.3) | 3 ± 0.3 (0.2) /8 ± 0.6 (0.3) | 3 ± 0.2 (0.1) /3 ± 0.6 (0.3) | 3 ± 0.8 (0.5) /3 ± 0.1 (0.1) | 7 ± 0.8 (0.5) | 3 ± 0.2 (0.1) /9 ± 0.2 (0.1) | 3 ± 0.5(0.3) /6 ± 0.5(0.3) |
After | 6 ± 0.5(0.3) | 3 ± 0.2 (0.1) /7 ± 0.2 (0.1) | 3 ± 0.5(0.3) /8 ± 0.7 (0.4) | 5 ± 0.4 (0.2) /5 ± 0.1 (0.1) | 3 ± 0.5(0.3) /3 ± 0.7 (0.4) | 9 ± 0.2 (0.1) | 3 ± 0.4 (0.2) /9 ± 0.2 (0.1) | 5 ± 0.3 (0.2) /8 ± 0.2 (0.1) | |
% of change | 8.3 | 0.0 /0.0 | 0.0 /0.0 | 40 /40 | 0.0 /0.0 | 22.2 | 0.0 /0.0 | 40 /25 | |
(p-value) | 0.288 | 1.000 /1.000 | 1.000 /1.000 | <0.001** /0.005* | 1.000 /1.000 | 0.014* | 1.000 /1.000 | 0.004* /0.003* | |
4/ Acinetobacter baumannii | Before | 5 ± 0.4 (0.2) | 3 ± 0.5(0.3) /3 ± 0.4 (0.2) | 3 ± 0.2 (0.1) /3 ± 0.4 (0.2) | 3.5 ± 0.5(0.3) /10 ± 0.6 (0.3) | 3 ± 0.3 (0.2) /7 ± 0.7 (0.4) | 7.5 ± 0.5(0.3) | 3 ± 0.7 (0.4) /10 ± 0.2 (0.1) | 3.5 ± 0.4 (0.2) /3.5 ± 0.5(0.3) |
After | 5 ± 0.6 (0.3) | 5 ± 0.3 (0.2) /6 ± 0.6 (0.3) | 5 ± 0.4 (0.2) /6 ± 0.2 (0.1) | 4 ± 0.5(0.3) /11 ± 0.8 (0.5) | 3 ± 0.8 (0.5) /7 ± 0.2 (0.1) | 9.5 ± 0.5(0.3) | 5 ± 0.5(0.3) /13 ± 0.4 (0.2) | 4 ± 0.2 (0.1) /5.5 ± 0.3 (0.2) | |
% of change | 0.0 | 40 /50 | 40 /50 | 12.5 /9.1 | 0.0 /0.0 | 21.1 | 40 /23.1 | 12.5 /36.4 | |
(p-value) | 1.000 | 0.004*/ 0.002* | <0.001** / <0.001** | 0.288 /0.158 | 1.000 /1.000 | 0.008* | 0.016* / <0.001** | 0.125 /0.004* | |
8/ Pseudomonas aeruginosa | Before | 3 ± 0.9 (0.5) | 3 ± 0.2 (0.1)/3 ± 0.5(0.3) | 4.5 ± 0.4 (0.2) /10 ± 0.2 (0.1) | 8 ± 0.4 (0.2) /12 ± 0.2 (0.1) | 6 ± 0.3 (0.2) /6 ± 0.5(0.3) | 8.5 ± 0.5(0.3) | 4.5 ± 0.5(0.3) /11 ± 0.2 (0.1) | 8 ± 0.2 (0.1) /12 ± 0.4 (0.2) |
After | 5 ± 0.3 (0.2) | 5 ± 0.4 (0.2)/6 ± 0.2 (0.1) | 6.5 ± 0.2 (0.1)/13 ± 0.5(0.3) | 9 ± 0.2 (0.1) /13.5 ± 0.5(0.3) | 7 ± 0.4 (0.2)/8 ± 0.2 (0.1) | 12 ± 0.3 (0.2) | 6 ± 0.2 (0.1) /13.5 ± 0.5(0.3) | 9 ± 0.1 (0.1) /14 ± 0.2 (0.1) | |
% of change | 40 | 40 /50 | 30.8 /23.1 | 11.1 /11.1 | 14.3 /25 | 29.2 | 25 /18.5 | 11.1 /14.3 | |
(p-value) | 0.22* | <0.001** / <0.001** | <0.001** / <0.001** | 0.018* /0.008* | 0.026* /0.003* | <0.001** | 0.008* / <0.001** | <0.001** / <0.001** | |
9/ Pseudomonas aeruginosa | Before | 3 ± 0.3 (0.2) | 3 ± 0.5(0.3) /3 ± 0.2 (0.1) | 3 ± 0.4 (0.2) /9 ± 0.2 (0.1) | 3 ± 0.2 (0.1) /8 ± 0.3 (0.2) | 8 ± 0.2 (0.1) /8 ± 0.5(0.3) | 5.5 ± 0.5(0.3) | 3 ± 0.2 (0.1) /8 ± 0.4 (0.2) | 3 ± 0.2 (0.1) /7 ± 0.1 (0.1) |
After | 4.5 ± 0.5(0.3) | 4.5 ± 0.5(0.3) /5 ± 0.2 (0.1) | 5 ± 0.2 (0.1) /11 ± 0.4 (0.2) | 5 ± 0.5(0.3) /11 ± 0.2 (0.1) | 9 ± 0.2 (0.1) /10 ± 0.3 (0.2) | 6.5 ± 0.3 (0.2) | 5 ± 0.1 (0.1) /10 ± 0.2 (0.1) | 5 ± 0.5(0.3) /10 ± 0.1 (0.1) | |
% of change | 33.3 | 33.3 /40 | 40 /18.2 | 40 /22.3 | 11.1 /20 | 15.4 | 40 /20 | 40 /30 | |
(p-value) | 0.011* | 0.021* / <0.001** | <0.001** / <0.001** | 0.003* / <0.001** | 0.004* /0.004* | 0.041* | <0.001** / <0.001** | 0.003* / <0.001** | |
13/ Enterobacter cloacae | Before | 4 ± 0.1 (0.1) | 3 ± 0.2 (0.1) /3 ± 0.5(0.3) | 7 ± 0.1 (0.1) /11 ± 0.4 (0.2) | 6 ± 0.2 (0.1) /11 ± 0.4 (0.2) | 6 ± 0.2 (0.1) /6 ± 0.1 (0.1) | 10 ± 0.2 (0.1) | 7 ± 0.1 (0.1) /12 ± 0.2 (0.1) | 6 ± 0.1 (0.1) /10 ± 0.2 (0.1) |
After | 4 ± 0.5(0.3) | 4 ± 0.1 (0.1) /4 ± 0.3 (0.2) | 8.5 ± 0.4 (0.2)/13 ± 0.2 (0.1) | 6.5 ± 0.1 (0.1) /12 ± 0.1 (0.1) | 6 ± 0.2 (0.1) /7 ± 0.3 (0.2) | 12 ± 0.3 (0.2) | 8.5 ± 0.1 (0.1) /14 ± 0.2 (0.1) | 6.5 ± 0.2 (0.1)/10.5 ± 0.3 (0.2) | |
% of change | 0.0 | 25 /25 | 17.6 /15.4 | 7.5 /8.3 | 0.0 /14.3 | 16.7 | 17.6 /14.3 | 7.5 /4.8 | |
(p-value) | 1.000 | <0.001** / 0.041* | 0.003* / <0.001** | 0.018* /0.014* | 1.000 /0.005* | <0.001** | <0.001** / <0.001** | 0.018* /0.074 |