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Table 6 Evaluation of MICs of certain antibiotics alone and with beta lactamase inhibitors alone (ECG) or in combination with gallic acid or thymol and selected permeabilizers before and after in vitro gamma irradiation

From: Natural outer membrane permeabilizers boost antibiotic action against irradiated resistant bacteria

Antibiotic (Ab) MICs (mg/L) before irradiation MICs (mg/L) after irradiation
Ab-alone +ECG +ECG+ Gallic acid +ECG +Thymol antibiotic disc with beta-lactamase inhibitors Ab- Alone +ECG +ECG+ Gallic acid +ECG + Thymol antibiotic disc with beta-lactamase inhibitors
Bacterial beta lactamase producer
Escherichia coli 2
 CFP 64 64 8 4 a32 64 64 8 4 a32
 PRL 128 128 16 4 b16 128 128 16 4 b16
Pseudomonas aeruginosa 8
 CFP 128 128 16 8 64 128 128 16 8 64
 PRL 128 128 8 8 64 128 128 8 8 64
Enterobacter cloacae 13
 CFP 32 32 4 4 16 64 64 8 8 32
 PRL 64 64 4 4 0.5 128 128 8 8 1
  1. Ab Antibiotic, ECG Epigallocatechin gallate, CFP Cefoperazone
  2. PRL = Piperacillin. a SCF = Cefoperazone/ sulbactum. b TZP = Piperacillin/ tazobactam