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Table 6 Evaluation of MICs of certain antibiotics alone and with beta lactamase inhibitors alone (ECG) or in combination with gallic acid or thymol and selected permeabilizers before and after in vitro gamma irradiation

From: Natural outer membrane permeabilizers boost antibiotic action against irradiated resistant bacteria

Antibiotic (Ab)

MICs (mg/L) before irradiation

MICs (mg/L) after irradiation

Ab-alone

+ECG

+ECG+ Gallic acid

+ECG +Thymol

antibiotic disc with beta-lactamase inhibitors

Ab- Alone

+ECG

+ECG+ Gallic acid

+ECG + Thymol

antibiotic disc with beta-lactamase inhibitors

Bacterial beta lactamase producer

Escherichia coli 2

 CFP

64

64

8

4

a32

64

64

8

4

a32

 PRL

128

128

16

4

b16

128

128

16

4

b16

Pseudomonas aeruginosa 8

 CFP

128

128

16

8

64

128

128

16

8

64

 PRL

128

128

8

8

64

128

128

8

8

64

Enterobacter cloacae 13

 CFP

32

32

4

4

16

64

64

8

8

32

 PRL

64

64

4

4

0.5

128

128

8

8

1

  1. Ab Antibiotic, ECG Epigallocatechin gallate, CFP Cefoperazone
  2. PRL = Piperacillin. a SCF = Cefoperazone/ sulbactum. b TZP = Piperacillin/ tazobactam