Natural outer membrane permeabilizers boost antibiotic action against irradiated resistant bacteria

Table 7 Evaluation of MICs of certain antibiotics alone and in the presence of beta lactamase inhibitors alone (quercetin) or in combination with gallic acid or thymol and selected permeabilizers before and after in vitro gamma irradiation

Antibiotics (Ab)	MICs (mg/L) before irradiation					MICs (mg/L) after irradiation
Antibiotics (Ab)	Ab-alone	+Q	+Q + Gallic acid	+Q + Thymol	Antibiotic disc with beta-lactamase inhibitors	Ab-alone	+Q	+Q + Gallic acid	+Q + Thymol	antibiotic disc with beta-lactamase inhibitors
Bacterial beta lactamase producer	Ab-alone	+Q	+Q + Gallic acid	+Q + Thymol	Antibiotic disc with beta-lactamase inhibitors	Ab-alone	+Q	+Q + Gallic acid	+Q + Thymol	antibiotic disc with beta-lactamase inhibitors
Escherichia coli ₂
CFP	64	32	8	2	^a32	64	32	8	2	32
PRL	128	32	8	4	^b16	128	32	8	4	16
Pseudomonas aeruginosa ₈
CFP	128	32	8	2	64	128	32	8	2	64
PRL	128	64	8	8	64	128	64	8	8	64
Enterobacter cloacae ₁₃
CFP	32	16	8	4	16	64	64	32	8	32
PRL	64	32	2	1	0.5	128	64	4	2	1

ISSN: 1423-0127