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Table 7 Evaluation of MICs of certain antibiotics alone and in the presence of beta lactamase inhibitors alone (quercetin) or in combination with gallic acid or thymol and selected permeabilizers before and after in vitro gamma irradiation

From: Natural outer membrane permeabilizers boost antibiotic action against irradiated resistant bacteria

Antibiotics (Ab) MICs (mg/L) before irradiation MICs (mg/L) after irradiation
Ab-alone +Q +Q + Gallic acid +Q + Thymol Antibiotic disc with beta-lactamase inhibitors Ab-alone +Q +Q + Gallic acid +Q + Thymol antibiotic disc with beta-lactamase inhibitors
Bacterial beta lactamase producer
Escherichia coli 2
 CFP 64 32 8 2 a32 64 32 8 2 32
 PRL 128 32 8 4 b16 128 32 8 4 16
Pseudomonas aeruginosa 8
 CFP 128 32 8 2 64 128 32 8 2 64
 PRL 128 64 8 8 64 128 64 8 8 64
Enterobacter cloacae 13
 CFP 32 16 8 4 16 64 64 32 8 32
PRL 64 32 2 1 0.5 128 64 4 2 1
  1. Q Quercetin, CFP Cefoperazone, PRL Piperacillin
  2. aSCF = Cefoperazone/ sulbactum b TZP = Piperacillin/ tazobactam