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Table 9 Beta lactamase assays in the presence of permeabilizer (thymol) and natural beta lactamase inhibitor (quercetin) for irradiated and non-irradiated Pseudomonas aeruginosa8 / Escherichia coli2

From: Natural outer membrane permeabilizers boost antibiotic action against irradiated resistant bacteria

Conc.

control

Pseudomonas aeruginosa 8 / Escherichia coli 2

aCefoperazone

aCefoperazone + thymol

aCefoperazone +thymol+quercetin

Before

After

Before

After

Before

After

128/64

0.271/0.273

0.123 ± 0.001/ 0.148 ± 0.001

0.142 ± 0.001/ 0.161 ± 0.002

0.037 ± 0.002/ 0.049 ± 0.006

0.044 ± 0.0006/ 0.053 ± 0.002

0.196 ± 0.002/ 0.215 ± 0.001

0.211 ± 0.0006/ 0.221 ± 0.001

64 /32

0.263 /0.263

0.119 ± 0.0006/ 0.139 ± 0.002

0.133 ± 0.003/ 0.160 ± 0.001

0.030 ± 0.001/ 0.048 ± 0.001

0.040 ± 0.001/ 0.050 ± 0.0005

0.183 ± 0.003/ 0.206 ± 0.001

0.203 ± 0.001/ 0.213 ± 0.0006

32/16

0.256/0.258

0.115 ± 0.001/ 0.128 ± 0.0006

0.130 ± 0.0006/ 0.148 ± 0.002

0.02 ± 0.001/ 0.045 ± 0.001

0.039 ± 0.0006/ 0.048 ± 0.002

0.179 ± 0.001/ 0.197 ± 0.001

0.20 ± 0.006/ 0.203 ± 0.001

  1. Control = Cefoperazone antibiotic in a solution of B-CHR-TMB
  2. a Mean results of triplicate experiments