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Fig. 4 | Journal of Biomedical Science

Fig. 4

From: Arginine vasopressin modulates electrical activity and calcium homeostasis in pulmonary vein cardiomyocytes

Fig. 4

Effects of arginine vasopressin (AVP) and its antagonist OPC 21268 on intracellular calcium (Ca2+) homeostasis and sarcoplasmic reticulum (SR) Ca2+ leak in pulmonary vein (PV) cardiomyocytes. a An example and average data of Ca2+i transients from control (n = 20), AVP (1 μM)-treated (n = 22), AVP (1 μM) combined with OPC 21268 (0.1 μM)-treated (n = 25), and OPC 21268 (0.1 μM)-treated (n = 11) PV cardiomyocytes. b An example and average data of caffeine-induced Ca2+i transients in control (n = 13) and PV cardiomyocytes treated with either AVP (1 μM, n = 15), AVP (1 μM) plus OPC 21268 (0.1 μM) (n = 21), or OPC 21268 (0.1 μM, n = 11). c An example and average data of SR Ca2+ leak from control (n = 14), AVP (1 μM)-treated (n = 16), and AVP (1 μM) combined with KN-93 (1 μM)-treated (n = 10) PV cardiomyocytes. *P < 0.05; **P < 0.01; ***P < 0.005

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