M2e-based universal influenza vaccines: a historical overview and new approaches to development

Table 1 Antigenic variants of M2e fragments

Major feature	2	3	4	5	6	7	8	9	10	11	12	13	14	15	16	17	18	19	20	21	22	23	24	Reference
The most conservative part of M2e	S	L	L	T	E	V	E	T	P															[18, 51]
TCN-031 and TCN-032 antibodies recognition site	S	L	L	T	E																			[37]
O19 antibody recognition site	S	L	L	T	E	V	E	T																[32]
L18 antibody recognition site			L	T	E	V	E	T	P	I	R	N
S1 antibody recognition site						V	E	T	P	I	R	N
Influenza A and B virus neutralizing activity in vitro	S	L	L	T	E	V	E	T	P	I	R													[77]
Presence of B-cell epitope and 14C2 antibody recognition site					E	V	E	T	P	I	R	N												[78]
High affinity of binding with HLA-A2; presence of T-cell epitope		L	L	T	E	V	E	T	P	I														[36]
Potential epitope							E	T	P	I	R													[94]
Presence of CTL-cell epitopes	S	L	L	T	E	V	E	T	P	I	R	N	E	W	G
Some critical residues for T-helpers																C	R	C	N	D	S	S	D
Recognition of HLA-B44-restricted CD8+ CTL line 124						V	E	T	P	I	R	N	E	W										[52]
MHC class II H-2d-restricted epitope							E	T	P	I	R	N	E	W	G	S	R							[26]
L66 antibody recognition site	S	L	L	T	E	V	E	T	P	I	R	N	E	W	G									[128]
N547 antibody recognition site		L	L	T	E	V	E	T	P	I	R	N	E	W	G
Z3G1 antibody recognition site		L	L	T	E	V	E	T	P	I	R
C40G1 antibody recognition site								T	P	I	R	N	E
14C2 antibody recognition site					E	V	E	T	P	I	R	N	E	W

ISSN: 1423-0127