Table 1 Antigenic variants of M2e fragments

The most conservative part of M2e

S

L

L

T

E

V

E

T

P

[18, 51]

TCN-031 and TCN-032 antibodies recognition site

S

L

L

T

E

[37]

O19 antibody recognition site

S

L

L

T

E

V

E

T

L18 antibody recognition site

L

T

E

V

E

T

P

I

R

N

S1 antibody recognition site

V

E

T

P

I

R

N

Influenza A and B virus neutralizing activity in vitro

S

L

L

T

E

V

E

T

P

I

R

[77]

Presence of B-cell epitope and 14C2 antibody recognition site

E

V

E

T

P

I

R

N

[78]

High affinity of binding with HLA-A2;

presence of T-cell epitope

L

L

T

E

V

E

T

P

I

[36]

Potential epitope

E

T

P

I

R

Presence of CTL-cell epitopes

S

L

L

T

E

V

E

T

P

I

R

N

E

W

Some critical residues for T-helpers

R

S

S

D

Recognition of HLA-B44-restricted CD8+ CTL line 124

V

E

T

P

I

R

N

E

W

[52]

MHC class II H-2d-restricted epitope

E

T

P

I

R

N

E

W

R

[26]

L66 antibody recognition site

S

L

L

T

E

V

E

T

P

I

R

N

E

W

N547 antibody recognition site

L

L

T

E

V

E

T

P

I

R

N

E

W

Z3G1 antibody recognition site

L

L

T

E

V

E

T

P

I

R

C40G1 antibody recognition site

T

P

I

R

N

E

14C2 antibody recognition site

E

V

E

T

P

I

R

N

E

W