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Table 1 Antigenic variants of M2e fragments

From: M2e-based universal influenza vaccines: a historical overview and new approaches to development

Major feature 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 23 24 Reference
The most conservative part of M2e S L L T E V E T P                [18, 51]
TCN-031 and TCN-032 antibodies recognition site S L L T E                    [37]
O19 antibody recognition site S L L T E V E T                 [32]
L18 antibody recognition site    L T E V E T P I R N            
S1 antibody recognition site       V E T P I R N            
Influenza A and B virus neutralizing activity in vitro S L L T E V E T P I R              [77]
Presence of B-cell epitope and 14C2 antibody recognition site      E V E T P I R N             [78]
High affinity of binding with HLA-A2;
presence of T-cell epitope 		  L L T E V E T P I               [36]
Potential epitope        E T P I R              [94]
Presence of CTL-cell epitopes S L L T E V E T P I R N E W G         
Some critical residues for T-helpers                 C R C N D S S D
Recognition of HLA-B44-restricted CD8+ CTL line 124       V E T P I R N E W           [52]
MHC class II H-2d-restricted epitope        E T P I R N E W G S R        [26]
L66 antibody recognition site S L L T E V E T P I R N E W G          [128]
N547 antibody recognition site   L L T E V E T P I R N E W G         
Z3G1 antibody recognition site   L L T E V E T P I R             
C40G1 antibody recognition site         T P I R N E           
14C2 antibody recognition site      E V E T P I R N E W          
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