Fig. 2

Measurement of thermal hyperalgesia of the mice. Behavioral response (thermal hyperalgesia) for mice in the CPIP model treated with propofol (10 mg/kg, PBS & lipofundin as control), single dose. ↑ represents the injection time point. The X-axis represents the time course (BL: basal level; 1 h, 2 h, 4 h: 1, 2, and 4 h after CPIP O-ring removal and drug injection; 1d, 2d, 3d, 5d, 7d: 1, 2, 3, 5, and 7 days after CPIP was induced.) Values are presented as mean ± SEM, n = 5–6 per group. Student’s t-test,* represents P < 0.05 vs. the CPIP PBS group and † represents P < 0.05 vs. the lipofundin group