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Table 2 Distribution of vitamin D binding protein (DBP) haplotypes (composed by rs16846876 and rs12512631) and its association with the patterns of clinical AIDS progression (LTNPs, MPs, RPs) in HIV infected patients

From: DBP rs16846876 and rs12512631 polymorphisms are associated with progression to AIDS naïve HIV-infected patients: a retrospective study

   Univariate Multivariate
Haplotypes Freq. aOR (95CI) p-value (*) q-value (**) aOR (95CI) p-value (*) q-value (**)
LTNPs vs MPs
 AC 0.366 0.85 (0.65; 1.10) 0.218 0.284 0.85 (0.63; 1.15) 0.292 0.378
 TT 0.307 1.45 (1.09; 1.93) 0.009 0.027 2.32 (4.95; 20.8) 0.018 0.054
 AT 0.321 0.86 (0.66; 1.13) 0.284 0.284 0.87 (0.65; 1.18) 0.378 0.378
LTNPs vs RPs
 AC 0.361 0.74 (0.53; 1.04) 0.080 0.120 0.63 (0.43; 0.93) 0.019 0.028
 TT 0.286 1.43 (1.01; 2.02) 0.044 0.120 1.64 (1.09; 2.46) 0.017 0.028
 AT 0.343 0.99 (0.73; 1.37) 0.973 0.973 1.07 (0.74; 1.54) 0.708 0.708
  1. Abbreviations: aOR Adjusted odds ratio, 95 CI 95% confidence interval, HIV Human immunodeficiency virus, DBP Vitamin D binding protein, LTNPs Long term non progressors, MPs moderate progressor, RPs Rapid progressor.
  2. Statistics: P-values were calculated using PLINK software by logistic regression adjusted by gender, age at HIV diagnosis, men who had sex with men and VDR rs2228570 polymorphism.
  3. (*)raw p-values
  4. (**)p-values corrected for multiple testing (q-value) using the false discovery rate (FDR) with Benjamini and Hochberg procedure (n = 3 haplotypes, multiple comparisons). Statistically significant differences are shown in bold.