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Table 2 Distribution of vitamin D binding protein (DBP) haplotypes (composed by rs16846876 and rs12512631) and its association with the patterns of clinical AIDS progression (LTNPs, MPs, RPs) in HIV infected patients

From: DBP rs16846876 and rs12512631 polymorphisms are associated with progression to AIDS naïve HIV-infected patients: a retrospective study

  

Univariate

Multivariate

Haplotypes

Freq.

aOR (95CI)

p-value (*)

q-value (**)

aOR (95CI)

p-value (*)

q-value (**)

LTNPs vs MPs

 AC

0.366

0.85 (0.65; 1.10)

0.218

0.284

0.85 (0.63; 1.15)

0.292

0.378

 TT

0.307

1.45 (1.09; 1.93)

0.009

0.027

2.32 (4.95; 20.8)

0.018

0.054

 AT

0.321

0.86 (0.66; 1.13)

0.284

0.284

0.87 (0.65; 1.18)

0.378

0.378

LTNPs vs RPs

 AC

0.361

0.74 (0.53; 1.04)

0.080

0.120

0.63 (0.43; 0.93)

0.019

0.028

 TT

0.286

1.43 (1.01; 2.02)

0.044

0.120

1.64 (1.09; 2.46)

0.017

0.028

 AT

0.343

0.99 (0.73; 1.37)

0.973

0.973

1.07 (0.74; 1.54)

0.708

0.708

  1. Abbreviations: aOR Adjusted odds ratio, 95 CI 95% confidence interval, HIV Human immunodeficiency virus, DBP Vitamin D binding protein, LTNPs Long term non progressors, MPs moderate progressor, RPs Rapid progressor.
  2. Statistics: P-values were calculated using PLINK software by logistic regression adjusted by gender, age at HIV diagnosis, men who had sex with men and VDR rs2228570 polymorphism.
  3. (*)raw p-values
  4. (**)p-values corrected for multiple testing (q-value) using the false discovery rate (FDR) with Benjamini and Hochberg procedure (n = 3 haplotypes, multiple comparisons). Statistically significant differences are shown in bold.
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Journal of Biomedical Science

ISSN: 1423-0127