Fig. 3

Total protein content and trophic factors in Intercept-platelet lysates. a Total proteins concentration (mg/ml). Concentrations in ng/ml of (b) brain-derived neurotropic factor (BDNF), c epidermal growth factor (EGF); d platelet-derived growth factor (PDGF)-AB, e vascular endothelial growth factor (VEGF). The values are expressed as the mean ± SD. I-PPL and I-HPPL were compared to the standard HPPL. ns: not statically significant. *p < 0.05; **p < 0.01 ***p < 0.001, ****p < 0.0001 vs. HPPL using One-way analysis of variance (ANOVA) followed by Fisher’s Least Significant Difference (LSD) test. Abbreviations: heat-treated platelet pellet lysate (HPPL), Intercept-platelet pellet lysate (I-PPL), heat-treated Intercept-platelet pellet lysate (I-HPPL), I-HPPL derived from pool 1 (I-HPPL1), I-HPPL derived from pool 2 (I-HPPL2); I-HPPL derived from pool 3 (I-HPPL3), I-HPPL derived from pool 4 (I-HPPL4). Each pool was prepared from 2 platelet units