Fig. 2

Summary of interaction between tumor and tumor-associated vasculature. Tumor cells can induce inflammatory response in myofibroblasts, tissue resident immune cells, and endothelial cells (black arrows). Both tumor cells and activated stromal cells can induce neoangiogenic response. Inflammation-activated endothelial cells in turn can respond by secreting cytokines to activate other stromal cells, and express adhesion molecules (red and blue short bars) that allow capture of circulating immune cells (green), and facilitate their extravasation. Activated endothelial cells, which lack coverage of perivascular cells, can also inhibit primary tumor growth while promoting metastasis