Fig. 7
From: Yy1 regulates Senp1 contributing to AMPA receptor GluR1 expression following neuronal depolarization
Model for Yy1 modulation in Senp1 expression and GluR1 protein levels following membrane depolarization. Yy1 is phosphorylated and binds to the Senp1 promoter where it recruits the BET family member Brd4 and activates Senp1 transcription in unstimulated neurons. Senp1 protein promotes the expression of GluR1 subunit. Upon neuronal depolarization, PP1/PP2A phosphatase activity is enhanced and dephosphorylates Yy1, resulting in its eviction from the Senp1 promoter. The Yy1-interacting partner Brd4 is also removed simultaneously. Consequently, the Senp1 protein expression is compromised resulting in a depletion of GluR1