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Fig. 3 | Journal of Biomedical Science

Fig. 3

From: Host immune response to anti-cancer camptothecin conjugated cyclodextrin-based polymers

Fig. 3

Adaptive immune responses after the second stimulation by the nanoparticle IT-101. (a)-(c) Changes in the proportions of cells in the myeloid cell lineage, including iDCs, neutrophils and macrophages, in peripheral blood, spleen and groin lymph nodes. (d)-(f) Changes in the proportions of cells in the lymphoid cell lineage, including Tc, Th, B and NK cells, in peripheral blood, spleen and groin lymph nodes. (g) Quantification of total T cells, labeled with CD3 and CD45, in peripheral blood, spleen and lymph node. (h) Increased T lymphocytes were observed in spleen after IT-101 treatment. Number of mice per group: 3–6 mice. The results are presented as the mean ± SD. *p < 0.05; **p < 0.005; ***p < 0.0001

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