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Fig. 3 | Journal of Biomedical Science

Fig. 3

From: Beyond defense: regulation of neuronal morphogenesis and brain functions via Toll-like receptors

Fig. 3

Non-classical TLR signaling pathways. a Three different endosomal TLRs use MYD88 to activate different pathways to fine-tune neuronal morphology. b TLR2 activates downstream signaling via TRIF in macrophages. c TLR5 can also use TRIF to deliver signal. d Different concentrations of ligand activate different TLR9 pathways in dendritic cells. e In addition to MYD88, TLR7 and TLR9 also use SARM1 to trigger cell death of neurons

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