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Fig. 1 | Journal of Biomedical Science

Fig. 1

From: Hypoxia and therapeutic treatment of EV-A71 with an immune modulator TLR7 agonist in a new immunocompetent mouse model

Fig. 1

Infection and pathogenesis with clinical isolates of EV-A71 in wild type strain 129 mice. a An illustration of the experimental design and time course using a wt-129 mouse model. b Disease and death were detected in the immunocompetent wild type mouse strain 129 experimentally infected with EV-A71. One-week-old newborns of wild type 129 mice were i.p. infected with clinical isolates of EV-A71 at two different viral titers. Disease manifestation was monitored daily. Clinical scores were defined as follows: 0, healthy; 1, hair loss, wasting, or ruffled hair; 2, limb weakness; 3, paralysis in only 1 limb; 4, paralysis in 2 to 4 limbs; 5, death. No significant clinical score was observed, when inoculated with 107 pfu/mouse or 108 UV-inactivated virus/mouse

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