Table 3 The frequency of alleles and genotypes of maternal P21-rs1059234, P21-rs1801270 and TP53-rs1042522 polymorphisms in PE women and controls
|  | PE (n = 226) | Control (n = 228) | P-value | OR(95% CI) | BC P-value |
|---|---|---|---|---|---|
 P21-rs1059234 | |||||
 CC, n(%) | 199 (88) | 199 (87) | – | 1 | |
 CT, n(%) | 22 (10) | 28 (12) | 0.43 | 0.7 (0.4–1.4) | 0.44 |
 TT, n(%) | 5 (2) | 1 (1) | 0.14 | 5 (0.6–43.2) | 0.11 |
 Dominant (CT + TT vs. CC) | 0.8 | 0.9 (0.5–1.6) | 0.8 | ||
 Recessive (TT vs. CC + CT) | 0.14 | 5 (0.6–44.3) | 0.11 | ||
 C, n(%) | 420 (93) | 426 (93) | 1 | ||
 T, n(%) | 32 (7) | 30 (7) | 0.8 | 1.1 (0.6–1.8) | – |
 P21-rs1801270 | |||||
 CC, n(%) | 200 (89) | 177 (78) | – | 1 | |
 CA, n(%) | 19 (8) | 49 (21) | 0.0002 | 0.3 (0.2–0.6) | 0.0001 |
 AA, n(%) | 7 (3) | 2 (1) | 0.16 | 3.1 (0.6–15.1) | 0.14 |
 Dominant (CA + AA vs. CC) | 0.002 | 0.4 (0.3–0.7) | 0.002 | ||
 Recessive (AA vs. CC + CA) | 0.11 | 3.6 (0.7–17.6) | 0.09 | ||
 C, n(%) | 419 (93) | 403 (88) | 1 | ||
 A, n(%) | 33 (7) | 53 (12) | 0.03 | 0.6 (0.4–0.9) | – |
 TP53-rs1042522 | |||||
 GG, n(%) | 65 (29) | 36 (16) | – | 1 | |
 GC, n(%) | 98 (43) | 101 (44) | 0.012 | 0.5 (0.3–0.9) | 0.012 |
 CC, n(%) | 63 (28) | 91 (40) | 0.0003 | 0.4 (0.2–0.6) | 0.0002 |
 Dominant (GC + CC vs. GG) | 0.001 | 0.5 (0.3–0.7) | 0.001 | ||
 Recessive (CC vs. GG + GC) | 0.007 | 0.6 (0.4–0.9) | 0.007 | ||
 G, n(%) | 228 (51) | 173 (38) | 1 | ||
 C, n(%) | 224 (49) | 283 (62) | 0.0001 | 0.6 (0.5–0.8) | – |