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Table 3 The frequency of alleles and genotypes of maternal P21-rs1059234, P21-rs1801270 and TP53-rs1042522 polymorphisms in PE women and controls

From: Analysis of polymorphisms, promoter methylation, and mRNA expression profile of maternal and placental P53 and P21 genes in preeclamptic and normotensive pregnant women

 PE (n = 226)Control (n = 228)P-valueOR(95% CI)BC P-value
P21-rs1059234
 CC, n(%)199 (88)199 (87)1
 CT, n(%)22 (10)28 (12)0.430.7 (0.4–1.4)0.44
 TT, n(%)5 (2)1 (1)0.145 (0.6–43.2)0.11
 Dominant (CT + TT vs. CC)0.80.9 (0.5–1.6)0.8
 Recessive (TT vs. CC + CT)0.145 (0.6–44.3)0.11
 C, n(%)420 (93)426 (93)1
 T, n(%)32 (7)30 (7)0.81.1 (0.6–1.8)
P21-rs1801270
 CC, n(%)200 (89)177 (78)1
 CA, n(%)19 (8)49 (21)0.00020.3 (0.2–0.6)0.0001
 AA, n(%)7 (3)2 (1)0.163.1 (0.6–15.1)0.14
 Dominant (CA + AA vs. CC)0.0020.4 (0.3–0.7)0.002
 Recessive (AA vs. CC + CA)0.113.6 (0.7–17.6)0.09
 C, n(%)419 (93)403 (88)1
 A, n(%)33 (7)53 (12)0.030.6 (0.4–0.9)
TP53-rs1042522
 GG, n(%)65 (29)36 (16)1
 GC, n(%)98 (43)101 (44)0.0120.5 (0.3–0.9)0.012
 CC, n(%)63 (28)91 (40)0.00030.4 (0.2–0.6)0.0002
 Dominant (GC + CC vs. GG)0.0010.5 (0.3–0.7)0.001
 Recessive (CC vs. GG + GC)0.0070.6 (0.4–0.9)0.007
 G, n(%)228 (51)173 (38)1
 C, n(%)224 (49)283 (62)0.00010.6 (0.5–0.8)
  1. BC P-value, Bonferroni corrected P-value