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Table 7 The promoter methylation status of the P21 and TP53 genes in PE women and control group

From: Analysis of polymorphisms, promoter methylation, and mRNA expression profile of maternal and placental P53 and P21 genes in preeclamptic and normotensive pregnant women

Methylation statusPE
(n = 109)
control
(n = 112)
OR (95% CI)P-valueBC
P-value
P21 promoter methylation
 UU, n (%)89 (81.7)105 (93.8)1
 UM, n (%)17 (15.6)7 (6.3)2.9 (1.1–7.2)0.0260.021
 MM, n (%)3 (2.8)0 (0)
 UM + MM vs UU, n (%)3.4 (1.4–8.3)0.0090.006
TP53 promoter methylation
 UU, n (%)84 (77.1)102 (91.1)1
 UM, n (%)17 (15.6)9 (8)2.3 (1–5.4)0.0580.053
 MM, n (%)8 (7.3)1 (0.9)9.7 (1.2–79.2)0.0340.010
 UM + MM vs UU, n (%)3 (1.4–6.7)0.0060.004
  1. U: Unmethylated: M: Methylated; BC P-value, Bonferroni corrected P-value