Table 7 The promoter methylation status of the P21 and TP53 genes in PE women and control group
Methylation status | PE (n = 109) | control (n = 112) | OR (95% CI) | P-value | BC P-value |
|---|---|---|---|---|---|
P21 promoter methylation | |||||
 UU, n (%) | 89 (81.7) | 105 (93.8) | 1 | – | |
 UM, n (%) | 17 (15.6) | 7 (6.3) | 2.9 (1.1–7.2) | 0.026 | 0.021 |
 MM, n (%) | 3 (2.8) | 0 (0) | – | – | |
 UM + MM vs UU, n (%) | 3.4 (1.4–8.3) | 0.009 | 0.006 | ||
TP53 promoter methylation | |||||
 UU, n (%) | 84 (77.1) | 102 (91.1) | 1 | – | |
 UM, n (%) | 17 (15.6) | 9 (8) | 2.3 (1–5.4) | 0.058 | 0.053 |
 MM, n (%) | 8 (7.3) | 1 (0.9) | 9.7 (1.2–79.2) | 0.034 | 0.010 |
 UM + MM vs UU, n (%) | 3 (1.4–6.7) | 0.006 | 0.004 | ||