The functional roles of IGF-1 variants in the susceptibility and clinical outcomes of mild traumatic brain injury

Table 8 Multiple neuropsychiatric symptoms of mild traumatic brain injury (mTBI) patients stratified by different insulin-like growth factor-1 (IGF-1) genotypes

SNP	Genotype	Patients without any neuropsychiatric symptoms (n = 61)	Patients with multiple neuropsychiatric symptoms (n = 18)	OR (95% CI)	Additive model^a
SNP	Genotype	Patients without any neuropsychiatric symptoms (n = 61)	Patients with multiple neuropsychiatric symptoms (n = 18)	OR (95% CI)	p-value	Bonferroni
rs35767	GG	27 (44.3)	9 (50.0)	0.79 (0.36–1.75)	0.557	1.000
	GA	26 (42.6)	7 (38.9)
	AA	8 (13.1)	2 (11.1)
rs5742612	AA	29 (47.5)	9 (52.9)	0.71 (0.31–1.65)	0.420	1.000
	AG	24 (39.3)	7 (41.2)
	GG	8 (13.1)	1 (5.9)
rs7136446	TT	40 (65.6)	5 (27.8)	3.73 (1.42–9.82)	0.005**	0.025*
	TC	19 (31.1)	11 (61.1)
	CC	2 (3.3)	2 (11.1)
rs972936	CC	15 (24.6)	1 (5.6)	2.58 (1.00–6.67)	0.041*	0.205
	CT	37 (60.7)	11 (61.1)
	TT	9 (14.8)	6 (33.3)
rs2072592	CC	29 (48.3)	10 (58.8)	0.72 (0.27–1.89)	0.493	1.000
	CT	28 (46.7)	6 (35.3)
	TT	3 (5.0)	1 (5.9)

^aAdjusted for sex and age. *indicates p < 0.05, **indicates p < 0.01. OR Odds ratio, CI Confidence interval

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