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Fig. 2 | Journal of Biomedical Science

Fig. 2

From: Development of therapeutic antibodies for the treatment of diseases

Fig. 2

Schematic overview of antibody humanization from murine antibodies (green domains) to fully human antibodies (orange domains) and associated suffixes. a The murine monoclonal antibody. b The chimeric monoclonal antibody: variable regions are of murine origin, and the rest of the chains are of human origin. c Humanized monoclonal antibody: only includes the hypervariable segments of murine origin. d Human monoclonal. CH: domains of the constant region of the heavy chain; CL: constant domain of the light chain; Fab and Fc: fragments resulting from proteolysis; VH: variable domain of the heavy chain; VL: variable domain of the light chain

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