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Table 1 US FDA-approved monoclonal antibody on the market

From: Development of therapeutic antibodies for the treatment of diseases

mAbBrand nameCompanyTargetFormatTechnologyIndication&US# Approval
Muromonab-CD3Orthoclone OKT3Centocor Ortho Biotech Products LP.CD3Murine IgG2aHybridoma/Janssen Biotech, IncKidney transplant rejection1986*
AbciximabReoproCentocor Inc./Eli Lilly/Janssen Biotech Inc.GPIIb/IIIaChimeric IgG1 FabHybridomaPrevention of blood clots in angioplasty1994
RituximabMabThera, RituxanBiogen Inc./Roche, F. Hoffmann-La Roche Ltd./Genentech Inc.CD20Chimeric IgG1HybridomaNon-Hodgkin lymphoma1997
PalivizumabSynagisMedImmune/AbbVie Inc.RSVHumanized IgG1HybridomaPrevention of respiratory syncytial virus infection1998
InfliximabRemicadeJanssen Biotech Inc.TNFαChimeric IgG1HybridomaCrohn’s disease1998
TrastuzumabHerceptinRoche, F. Hoffmann-La Roche, Ltd./Genentech Inc.HER2Humanized IgG1HybridomaBreast cancer1998
AlemtuzumabCampath, LemtradaBerlex Inc./Genzyme Corp./Millennium Pharmaceuticals Inc.CD52Humanized IgG1HybridomaChronic myeloid leukemia2001
AdalimumabHumiraAbbVie Inc.TNFαHuman IgG1Phage displayRheumatoid arthritis2002
Ibritumomab tiuxetanZevalinBiogen Inc./Schering AG/Spectrum Pharmaceuticals Inc.CD20Murine IgG1HybridomaNon-Hodgkin lymphoma2002
OmalizumabXolairRoche, F. Hoffmann-La Roche, Ltd./Genentech Inc./Novartis Pharmaceuticals Corp./Tanox Inc.IgEHumanized IgG1HybridomaAsthma2003
CetuximabErbituxBristol-Myers Squibb/Merck & Co. Inc./Eli Lilly/ImClone Systems Inc.EGFRChimeric IgG1HybridomaColorectal cancer2004
BevacizumabAvastinRoche, F. Hoffmann-La Roche, Ltd./Genentech Inc.VEGF-AHumanized IgG1HybridomaColorectal cancer2004
NatalizumabTysabriBiogen Inc./Elan Pharmaceuticals International, Ltd.ITGA4Humanized IgG4HybridomaMultiple sclerosis2004
PanitumumabVectibixAmgenEGFRHuman IgG2Transgenic miceColorectal cancer2006
RanibizumabLucentisRoche, F. Hoffmann-La Roche Ltd./Genentech Inc./Novartis Pharmaceuticals Corp.VEGF-AHumanized IgG1 FabHybridomaMacular degeneration2006
EculizumabSolirisAlexion Pharmaceuticals Inc.C5Humanized IgG2/4HybridomaParoxysmal nocturnal hemoglobinuria2007
Certolizumab pegolCimziaCelltech, UCB.TNFαHumanized Fab, pegylatedHybridomaCrohn’s disease2008
UstekinumabStelaraMedarex/Centocor Ortho Biotech Inc./Janssen Biotech Inc.IL-12/23Human IgG1Transgenic micePsoriasis2009
CanakinumabIlarisNovartis Pharmaceuticals Corp.IL-1βHuman IgG1Transgenic miceMuckle-Wells syndrome2009
GolimumabSimponiCentocor Ortho Biotech Inc./Janssen Biotech Inc.TNFαHuman IgG1Transgenic miceRheumatoid and psoriatic arthritis, ankylosing spondylitis2009
OfatumumabArzerraGenmab A/S /GlaxoSmithKline /Novartis.CD20Human IgG1Transgenic miceChronic lymphocytic leukemia2009
TocilizumabRoActemra, ActemraChugai Pharmaceutical Co., Ltd./Roche, F. Hoffmann-La Roche. Ltd./Genentech Inc.IL-6RHumanized IgG1HybridomaRheumatoid arthritis2010
DenosumabXgeva, ProliaAmgenRANKLHuman IgG2Transgenic miceBone loss2010
BelimumabBenlystaGlaxoSmithKline /Human Genome Sciences Inc.BLySHuman IgG1Phage displaySystemic lupus erythematosus2011
IpilimumabYervoyBristol-Myers Squibb/MedarexCTLA-4Human IgG1Transgenic miceMetastatic melanoma2011
Brentuximab vedotinAdcetrisSeattle genetics Inc./Takeda Pharmaceutical Co., Ltd.CD30Chimeric IgG1; ADCHybridomaHodgkin lymphoma, systemic anaplastic large cell lymphoma2011
PertuzumabPerjetaRoche, F. Hoffmann-La Roche, Ltd./Genentech Inc.HER2Humanized IgG1HybridomaBreast Cancer2012
Trastuzumab emtansineKadcylaRoche, F. Hoffmann-La Roche Ltd./Genentech Inc./ImmunoGen Inc.HER2Humanized IgG1; ADCHybridomaBreast cancer2012
RaxibacumabAbthraxGlaxoSmithKline /Human Genome Sciences Inc. (HGSI)B. anthrasis PAHuman IgG1Transgenic miceAnthrax infection2012
ObinutuzumabGazyva, GazyvaroBiogen Inc./Roche, F. Hoffmann-La Roche, Ltd./Genentech Inc.CD20Humanized IgG1 GlycoengineeredHybridomaChronic lymphocytic leukemia2013
SiltuximabSylvantCentocor Inc./Janssen Biotech Inc./Janssen-Cilag International NVIL-6Chimeric IgG1HybridomaCastleman disease2014
RamucirumabCyramzaEli Lilly/ImClone Systems Inc.VEGFR2Human IgG1Phage displayGastric cancer2014
VedolizumabEntyvioGenentech Inc./Millennium Pharmaceuticals Inc./Takeda Pharmaceuticals U.S.A. Inc.α4β7 integrinHumanized IgG1HybridomaUlcerative colitis, Crohn disease2014
BlinatumomabBlincytoAmgenCD19, CD3Murine bispecific tandem scFvHybridomaAcute lymphoblastic leukemia2014
NivolumabOpdivoBristol-Myers Squibb/Ono Pharmaceutical Co., Ltd.PD-1Human IgG4Transgenic miceMelanoma, non-small cell lung cancer2014
PembrolizumabKeytrudaMerck & Co. Inc.PD-1Humanized IgG4HybridomaMelanoma2014
IdarucizumabPraxbindBoehringer Ingelheim PharmaceuticalsDabigatranHumanized FabHybridomaReversal of dabigatran-induced anticoagulation2015
NecitumumabPortrazzaEli Lilly/ImClone Systems Inc.EGFRHuman IgG1Phage displayNon-small cell lung cancer2015
DinutuximabUnituxinUnited Therapeutics CorporationGD2Chimeric IgG1HybridomaNeuroblastoma2015
SecukinumabCosentyxNovartis Pharmaceuticals Corp.IL-17αHuman IgG1Transgenic micePsoriasis2015
MepolizumabNucalaCentocor Inc./GlaxoSmithKlineIL-5Humanized IgG1HybridomaSevere eosinophilic asthma2015
AlirocumabPraluentRegeneron Pharmaceuticals Inc./Sanofi.PCSK9Human IgG1Transgenic miceHigh cholesterol2015
EvolocumabRepathaAmgen/Amgen Astellas BioPharma K.K.PCSK9Human IgG2Transgenic miceHigh cholesterol2015
DaratumumabDarzalexGenmab A/S/Janssen Biotech Inc.CD38Human IgG1Transgenic miceMultiple myeloma2015
ElotuzumabEmplicitiBristol-Myers Squibb/AbbVie Inc.SLAMF7Humanized IgG1HybridomaMultiple myeloma2015
IxekizumabTaltzEli LillyIL-17αHumanized IgG4HybridomaPsoriasis2016
ReslizumabCinqaero, CinqairCelltech, UCB/Schering-Plough/Teva Pharmaceutical Industries, Ltd.IL-5Humanized IgG4HybridomaAsthma2016
OlaratumabLartruvoEli Lilly/ImClone Systems Inc.PDGFRαHuman IgG1Transgenic miceSoft tissue sarcoma2016
BezlotoxumabZinplavaMerck & Co. Inc.Clostridium difficile enterotoxin BHuman IgG1Transgenic micePrevention of Clostridium difficile infection recurrence2016
AtezolizumabTecentriqRoche, F. Hoffmann-La Roche, Ltd./Genentech Inc.PD-L1Humanized IgG1HybridomaBladder cancer2016
ObiltoxaximabAnthimElusys Therapeutics Inc.B. anthrasis PAChimeric IgG1HybridomaPrevention of inhalational anthrax2016
Inotuzumab ozogamicinBesponsaWyeth Pharmaceuticals/Pfizer.CD22Humanized IgG4HybridomaAcute lymphoblastic leukemia2017
BrodalumabSiliq, LumicefMedImmune/Amgen/Kyowa Hakko Kirin /AstraZeneca/Valeant Pharmaceuticals International Inc.IL-17RHuman IgG2Transgenic micePlaque psoriasis2017
GuselkumabTremfyaMorphoSys/Janssen Biotech Inc.IL-23 p19Human IgG1Phage displayPlaque psoriasis2017
DupilumabDupixentRegeneron Pharmaceuticals Inc./SanofiIL-4RαHuman IgG4Transgenic miceAtopic dermatitis2017
SarilumabKevzaraRegeneron Pharmaceuticals Inc./SanofiIL-6RHuman IgG1Transgenic miceRheumatoid arthritis2017
AvelumabBavencioMerck Serono International S.A./PfizerPD-L1Human IgG1Phage displayMerkel cell carcinoma2017
OcrelizumabOcrevusBiogen Inc./Roche, F. Hoffmann-La Roche, Ltd./Genentech Inc./SIGMA-TAU Industrie Farmaceutiche Riunite S.p.A.CD20Humanized IgG1HybridomaMultiple sclerosis2017
EmicizumabHemlibraChugai Pharmaceutical Co., Ltd./Roche, F. Hoffmann-La Roche, Ltd.Factor IXa, XHumanized IgG4, bispecificHybridomaHemophilia A2017
BenralizumabFasenraMedImmune/Kyowa Hakko Kirin/AstraZenecaIL-5RαHumanized IgG1HybridomaAsthma2017
Gemtuzumab ozogamicinMylotargPfizerCD33Humanized IgG4; ADCHybridomaAcute myeloid leukemia2017
DurvalumabImfinziMedImmune/AstraZenecaPD-L1Human IgG1Transgenic miceBladder cancer2017
BurosumabCrysvitaKyowa Hakko Kirin/Ultragenyx Pharmaceutical Inc.FGF23Human IgG1Transgenic miceX-linked hypophosphatemia2018
LanadelumabTakhzyroDyax Corp.Plasma kallikreinHuman IgG1Phage displayHereditary angioedema attacks2018
MogamulizumabPoteligeoKyowa Hakko KirinCCR4Humanized IgG1HybridomaMycosis fungoides or Sézary syndrome2018
ErenumabAimovigNovartisCGRPRHuman IgG2Transgenic miceMigraine prevention2018
GalcanezumabEmgalityEli LillyCGRPHumanized IgG4HybridomaMigraine prevention2018
TildrakizumabIlumyaMerck & Co. Inc./Sun Pharmaceutical Industries, Ltd.IL-23 p19Humanized IgG1HybridomaPlaque psoriasis2018
CemiplimabLibtayoRegeneron Pharmaceuticals Inc.PD-1Human mAbTransgenic miceCutaneous squamous cell carcinoma2018
EmapalumabGamifantNovImmmuneIFNγHuman IgG1Phage displayPrimary hemophagocytic lymphohistiocytosis2018
FremanezumabAjovyTeva Pharmaceutical Industries, Ltd.CGRPHumanized IgG2HybridomaMigraine prevention2018
IbalizumabTrogarzoTaimed Biologics Inc./Theratechnologies Inc.CD4Humanized IgG4HybridomaHIV infection2018
Moxetumomab pasudodoxLumoxitiMedImmune/AstraZenecaCD22Murine IgG1 dsFvPhage displayHairy cell leukemia2018
RavulizumabUltomirisAlexion Pharmaceuticals Inc.C5humanized IgG2/4HybridomaParoxysmal nocturnal hemoglobinuria2018
CaplacizumabCabliviAblynxvon Willebrand factorHumanized
Nanobody
HybridomaAcquired thrombotic thrombocytopenic purpura2019
RomosozumabEvenityAmgen/UCBSclerostinHumanized IgG2HybridomaOsteoporosis in postmenopausal women at increased risk of fracture2019
RisankizumabSkyriziBoehringer Ingelheim Pharmaceuticals/ AbbVie Inc.IL-23 p19Humanized IgG1HybridomaPlaque psoriasis2019
Polatuzumab vedotinPolivyRoche, F. Hoffmann-La Roche, Ltd.CD79βHumanized IgG1 ADCHybridomaDiffuse large B-cell lymphoma2019
BrolucizumabBeovuNovartis Pharmaceuticals Corp.VEGF-AHumanized scFvHybridoma$Macular degeneration2019
CrizanlizumabAdakveoNovartis Pharmaceuticals Corp.P-selectinHumanized IgG2HybridomaSickle cell disease2019
  1. *Marketing end date on July 30th, 2011
  2. #Year of the first US FDA approval
  3. &Indication of the first US FDA approval
  4. $Rabbit hybridoma technology