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Fig. 2 | Journal of Biomedical Science

Fig. 2

From: Photoacoustic imaging of cells in a three-dimensional microenvironment

Fig. 2

Schematics of two types of PAM system: (a) OR-PAM and (b) AR-PAM. In this setup, 3D tumor spheres labeled with contrast agents are cultured in a cuboidal matrix hydrogel for PA imaging. Note that the laser light is focused in OR-PAM but unfocused in AR-PAM, respectively. Once the laser energy is delivered into the 3D cell culture and absorbed by endogenous or exogenous contrast agents, the absorbed energy is converted into heat, leading to thermal expansion. Ultrasound signals are then generated and detected by the transducer located at the top of the samples

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