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Fig. 4 | Journal of Biomedical Science

Fig. 4

From: Circular RNA circ_0003204 inhibits proliferation, migration and tube formation of endothelial cell in atherosclerosis via miR-370-3p/TGFβR2/phosph-SMAD3 axis

Fig. 4

TGFβR2 is the downstream target of miR-370. a and c QRT-PCR analysis of TGFβR2 expression after transfection of miR-370 mimics or inhibitor to ox-LDL-treated HAECs for 48 h. b and d Western blot analysis of TGFβR2 protein expression after transfection of miR-370 mimics or inhibitor to ox-LDL-treated HAECs for 48 h. e Putative miR-370 binding sites in TGFβR2. The predictive complementary sequences are indicated in red. f Relative luciferase activity of wild-type and 3’UTR mutant constructs of TGFβR2 cotransfected with miR-370 mimics and miRNA negative control. NC, negative control; UTR, untranslated regions. Data are means ± SD of three experiments. *P < 0.05

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