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Fig. 2 | Journal of Biomedical Science

Fig. 2

From: Interplays between Enterovirus A71 and the innate immune system

Fig. 2

Interactions between EV-A71 and inflammasomes. Upon EV-A71 infection, EV-A71 2B and 3D interact NLRP3 to trigger NLRP3 inflammasome activation. AIM2 inflammasome is activated by the transfection of EV71 viral RNA. AIM2 plays a role in the restriction of EV-A71 replication. Meanwhile, EV-A71 viral factors 2A and 3C are shown to counteract NLRP3 inflammasome activation by targeting NLRP3 and GSDMD, respectively

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