From: Interplays between Enterovirus A71 and the innate immune system
PRRs | Cell lines and types | PAMPs and sensing mechanisms | References |
---|---|---|---|
TLR4 | Human Mo-DCs, TLR4-transfected HEK293 cells | Viral particles | [40] |
TLR3 | Human Mo-DCs, Mouse BMMs, TLR3-transfected HEK293 cells | dsRNA | |
MDA5 | Mouse MEFs, MDA5-transfected HeLa cells | dsRNA | |
TLR7 | THP-1, Mouse BMMs | ssRNA | [46] |
NLRP3 | Human PBMCs, Mouse BMDCs, THP-1, Mono Mac 6 | 1. EV-A71 2B protein induces the redistribution of NLRP3 2. EV-A71 3D protein interacts with the LRR domain of NLRP3 | |
AIM2 | SK-N-SH | Not determined | [50] |
TLR9 | Mouse pDCs, TLR9-transfected HEK293 cells | Host DNA from dying EV-A71-infected cells | [51] |