From: Interplays between Enterovirus A71 and the innate immune system
PRRs | Cell lines and types | PAMPs and sensing mechanisms | References |
---|---|---|---|
TLR4 |
Human Mo-DCs, TLR4-transfected HEK293 cells | Viral particles | [40] |
TLR3 |
Human Mo-DCs, Mouse BMMs, TLR3-transfected HEK293 cells | dsRNA | [41,42,43] |
MDA5 |
Mouse MEFs, MDA5-transfected HeLa cells | dsRNA | [44, 45] |
TLR7 |
THP-1, Mouse BMMs | ssRNA | [46] |
NLRP3 |
Human PBMCs, Mouse BMDCs, THP-1, Mono Mac 6 |
1. EV-A71 2B protein induces the redistribution of NLRP3 2. EV-A71 3D protein interacts with the LRR domain of NLRP3 | [47,48,49] |
AIM2 | SK-N-SH | Not determined | [50] |
TLR9 |
Mouse pDCs, TLR9-transfected HEK293 cells | Host DNA from dying EV-A71-infected cells | [51] |