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Table 1 PRRs detect EV-A71 infection

From: Interplays between Enterovirus A71 and the innate immune system

PRRs

Cell lines and types

PAMPs and sensing mechanisms

References

TLR4

Human Mo-DCs,

TLR4-transfected HEK293 cells

Viral particles

[40]

TLR3

Human Mo-DCs, Mouse BMMs,

TLR3-transfected HEK293 cells

dsRNA

[41,42,43]

MDA5

Mouse MEFs,

MDA5-transfected HeLa cells

dsRNA

[44, 45]

TLR7

THP-1,

Mouse BMMs

ssRNA

[46]

NLRP3

Human PBMCs,

Mouse BMDCs,

THP-1,

Mono Mac 6

1. EV-A71 2B protein induces the redistribution of NLRP3

2. EV-A71 3D protein interacts with the LRR domain of NLRP3

[47,48,49]

AIM2

SK-N-SH

Not determined

[50]

TLR9

Mouse pDCs,

TLR9-transfected HEK293 cells

Host DNA from dying EV-A71-infected cells

[51]

  1. Human Mo-DCs human monocyte-derived DCs, HEK293 human embryonic kidney 293, MEFs mouse embryonic fibroblasts, THP-1 human monocytic cell lines, BMMs bone marrow-derived macrophages, PBMCs peripheral blood mononuclear cells, BMDCs bone marrow-derived dendritic cells, SK-N-SH human neuroblastoma, Mono Mac 6 human monocytic cell line, pDCs plasmacytoid DCs