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Table 1 PRRs detect EV-A71 infection

From: Interplays between Enterovirus A71 and the innate immune system

PRRs Cell lines and types PAMPs and sensing mechanisms References
TLR4 Human Mo-DCs,
TLR4-transfected HEK293 cells
Viral particles [40]
TLR3 Human Mo-DCs, Mouse BMMs,
TLR3-transfected HEK293 cells
dsRNA [41,42,43]
MDA5 Mouse MEFs,
MDA5-transfected HeLa cells
dsRNA [44, 45]
TLR7 THP-1,
Mouse BMMs
ssRNA [46]
NLRP3 Human PBMCs,
Mouse BMDCs,
THP-1,
Mono Mac 6
1. EV-A71 2B protein induces the redistribution of NLRP3
2. EV-A71 3D protein interacts with the LRR domain of NLRP3
[47,48,49]
AIM2 SK-N-SH Not determined [50]
TLR9 Mouse pDCs,
TLR9-transfected HEK293 cells
Host DNA from dying EV-A71-infected cells [51]
  1. Human Mo-DCs human monocyte-derived DCs, HEK293 human embryonic kidney 293, MEFs mouse embryonic fibroblasts, THP-1 human monocytic cell lines, BMMs bone marrow-derived macrophages, PBMCs peripheral blood mononuclear cells, BMDCs bone marrow-derived dendritic cells, SK-N-SH human neuroblastoma, Mono Mac 6 human monocytic cell line, pDCs plasmacytoid DCs