Skip to main content
Fig. 3 | Journal of Biomedical Science

Fig. 3

From: Mode of action of granulocyte-colony stimulating factor (G-CSF) as a novel therapy for stroke in a mouse model

Fig. 3

Effect of G-CSF on expression of Mitochondrial stress proteins. a Levels of OPA1 in the ischemic frontal (F (2, 19) = 147.1, p < 0.0001) and middle (F (2, 19) = 33.75, p < 0.0001) region of mouse’s brain on day 4. b Western blot analyses measuring levels of OPA1 in the ischemic frontal (F (2, 28) = 5.366, p = 0.0106) and middle (F (2, 27) = 4.747, p = 0.0171) region of mouse’s brain on day 7. c Levels of DRP 1 in the ischemic frontal (F (2, 22) = 37.78, p < 0.0001) and middle (F (2, 18) = 16.49, p < 0.0001) region of mouse’s brain on day 4. d Levels of DRP 1 in the ischemic frontal (F (2, 21) = 0.002564, p = 0.9974) & middle (F (2, 22) = 0.001202, p = 0.9988) and P-DRP1 levels in the ischemic frontal (F (2, 14) = 5.692, p = 0.0155) & middle (F (2, 11) = 4.043, p = 0.0483) regions of mouse’s brain on day 7. e Western blot analyses indicating ratio of levels of P-DRP1/DRP1 in the ischemic frontal (F (2, 15) = 16.50, p = 0.0002) and middle (F (2, 12) = 0.4053, p = 0.6755) regions of mouse’s brain on day 7. f P53 expression levels in the frontal (F (2, 13) = 4.803, p = 0.0274) and middle (F (2, 9) = 6.150, p = 0.0207 Vs Sham); (F (2, 10) = 3.801, p = 0.0592 vs BCAO) region of brain. Representative western blots are presented with cropped blot panels showing target protein signals and control (GAPDH) protein signals in separate panels derived from the same gel. Graphs show mean ± SEM. * and # significant compared to sham & vehicle treated groups, respectively by ANOVA and Tukey post hoc tests (n = 5, p < 0.05)

Back to article page