Skip to main content


Fig. 8 | Journal of Biomedical Science

Fig. 8

From: Mode of action of granulocyte-colony stimulating factor (G-CSF) as a novel therapy for stroke in a mouse model

Fig. 8

Schematic representation of G-CSF mechanism of action in BCAO mouse model. 1 – G-CSF binds to G-CSF receptors resulting in phosphorylation and activation of JAK2; 2 – Activated JAK2 then activates four transduction pathways including STAT3, PI3K, ERK1/2 and ERK5; 3 – Activated STAT3 is then translocated into the nucleus and turns on the transcription of anti-apoptotic proteins, Bcl-2 and Bcl-XL whereas activated PI3K and ERK1/2 inhibit the pro-apoptotic protein, BAD, resulting in the protection of mitochondria; 4 – Increase level of Bcl2 which combines with Beclin 1 and forms complex that inhibits autophagy activation; 5 – Activated PI3K further activate Akt/p-Akt which in turn inhibits Ask-1, one of the proteins involved in ER stress pathways resulting in decreased level of CHOP and inactivation of the downstream signaling molecules involved in apoptosis including BAD and Bim

Back to article page