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Table 2 Correlation analysis between the transcriptional profile of Mtb-Specific CD4 + T cells and clinical data from HIV-TB patients. Table shows the results of CD4 + T cells expressing (A) CD25, FoxP3, ROR-γt or T-bet and the co-expression of FoxP3, ROR-γt and T-bet. Additionally, (B) Tregs (CD25 + FoxP3+) and uTregs (CD25-FoxP3+) subsets and the co-expression of the transcription factors ROR-γt or T-bet within each subpopulation were analyzed. A comparison of the percentage of different CD4+ Th cells was performed with total and nadir CD4 + T cell counts, CD4/CD8 ratio and viral load. Number of values (n), Spearman’s rank correlation coefficient (r), and p value are indicated

From: 7-oxo-DHEA enhances impaired M. tuberculosis-specific T cell responses during HIV-TB coinfection

Clinical parameterFoxP3+ROR-γt+T-bet+CD25+FoxP3+ ROR-γt+ROR-γt + T-bet+FoxP3+ T-bet+
A
CD4 + T cell count (cell/ml)n = 14n = 14n = 15n = 15n = 14n = 14n = 15
r = −0.66r = 0.14r = 0.48r = − 0.45r = 0.29r = 0.37r = − 0.49
p = 0.0035p = 0.31p = 0.041p = 0.045p = 0.16p = 0.19p = 0.029
Nadir CD4 T cell count (cell/ml)n = 15n = 14n = 14n = 15n = 14n = 14n = 15
r = −0.65r = 0.55r = 0.65r = − 0.41r = 0.091r = 0.61r = − 0.29
p = 0.021p = 0.45p = 0.014p = 0.22p = 0.40p = 0.033p = 0.28
CD4/CD8 T cell ration = 15n = 14n = 15n = 15n = 14n = 14n = 15
r = −0.55r = − 0.12r = 0.23r = − 0.27r = − 0.034r = 0.13r = − 0.17
p = 0.018p = 0.35p = 0.21p = 0.16p = 0.49p = 0.63p = 0.27
Viral load (copies/ml)n = 15n = 14n = 15n = 15n = 14n = 14n = 15
r = 0.56r = 0.25r = − 0.14r = 0.41r = 0.15r = 0.013r = 0.071
p = 0.015p = 0.19p = 0.32p = 0.13p = 0.30p = 0.97p = 0.80
B      
Clinical parameterTregsTregs ROR-γt+Tregs
T-bet+
uTregsuTregs ROR-γt+uTregs
T-bet+
CD4 + T cell count (cell/ml)n = 15n = 14n = 15n = 15n = 14n = 15
r = −0.71r = 0.33r = − 0.17r = − 0.48r = 0.059r = − 0.22
p = 0.015p = 0.25p = 0.54p = 0.036p = 0.84p = 0.42
Nadir CD4 T cell count (cell/ml)n = 15n = 15n = 14n = 14n = 14n = 14
r = − 0.43r = 0.16r = − 0.19r = − 0.29r = − 0.27r = − 0.22
p = 0.090p = 0.66p = 0.58p = 0.19p = 0.44p = 0.49
CD4/CD8 T cell ration = 15n = 14n = 15n = 15n = 14n = 15
r = − 0.53r = 0r = − 0.17r = − 0.27r = − 0.059r = − 0.16
p = 0.022p = 0.50p = 0.55p = 0.15p = 0.84p = 0.55
Viral Load (copies/ml)n = 14n = 14n = 14n = 14n = 14n = 14
r = 0.42r = 0.0083r = − 0.23r = 0.17r = − 0.033r = − 0.14
p = 0.14r = 0.98p = 0.43p = 0.27p = 0.92p = 0.63