Table 2 Correlation analysis between the transcriptional profile of Mtb-Specific CD4 + T cells and clinical data from HIV-TB patients. Table shows the results of CD4 + T cells expressing (A) CD25, FoxP3, ROR-γt or T-bet and the co-expression of FoxP3, ROR-γt and T-bet. Additionally, (B) Tregs (CD25 + FoxP3+) and uTregs (CD25-FoxP3+) subsets and the co-expression of the transcription factors ROR-γt or T-bet within each subpopulation were analyzed. A comparison of the percentage of different CD4+ Th cells was performed with total and nadir CD4 + T cell counts, CD4/CD8 ratio and viral load. Number of values (n), Spearman’s rank correlation coefficient (r), and p value are indicated
From: 7-oxo-DHEA enhances impaired M. tuberculosis-specific T cell responses during HIV-TB coinfection
Clinical parameter | FoxP3+ | ROR-γt+ | T-bet+ | CD25+ | FoxP3+ ROR-γt+ | ROR-γt + T-bet+ | FoxP3+ T-bet+ |
|---|---|---|---|---|---|---|---|
A | |||||||
CD4 + T cell count (cell/ml) | n = 14 | n = 14 | n = 15 | n = 15 | n = 14 | n = 14 | n = 15 |
r = −0.66 | r = 0.14 | r = 0.48 | r = − 0.45 | r = 0.29 | r = 0.37 | r = − 0.49 | |
p = 0.0035 | p = 0.31 | p = 0.041 | p = 0.045 | p = 0.16 | p = 0.19 | p = 0.029 | |
Nadir CD4 T cell count (cell/ml) | n = 15 | n = 14 | n = 14 | n = 15 | n = 14 | n = 14 | n = 15 |
r = −0.65 | r = 0.55 | r = 0.65 | r = − 0.41 | r = 0.091 | r = 0.61 | r = − 0.29 | |
p = 0.021 | p = 0.45 | p = 0.014 | p = 0.22 | p = 0.40 | p = 0.033 | p = 0.28 | |
CD4/CD8 T cell ratio | n = 15 | n = 14 | n = 15 | n = 15 | n = 14 | n = 14 | n = 15 |
r = −0.55 | r = − 0.12 | r = 0.23 | r = − 0.27 | r = − 0.034 | r = 0.13 | r = − 0.17 | |
p = 0.018 | p = 0.35 | p = 0.21 | p = 0.16 | p = 0.49 | p = 0.63 | p = 0.27 | |
Viral load (copies/ml) | n = 15 | n = 14 | n = 15 | n = 15 | n = 14 | n = 14 | n = 15 |
r = 0.56 | r = 0.25 | r = − 0.14 | r = 0.41 | r = 0.15 | r = 0.013 | r = 0.071 | |
p = 0.015 | p = 0.19 | p = 0.32 | p = 0.13 | p = 0.30 | p = 0.97 | p = 0.80 | |
B | |||||||
Clinical parameter | Tregs | Tregs ROR-γt+ | Tregs T-bet+ | uTregs | uTregs ROR-γt+ | uTregs T-bet+ | |
CD4 + T cell count (cell/ml) | n = 15 | n = 14 | n = 15 | n = 15 | n = 14 | n = 15 | |
r = −0.71 | r = 0.33 | r = − 0.17 | r = − 0.48 | r = 0.059 | r = − 0.22 | ||
p = 0.015 | p = 0.25 | p = 0.54 | p = 0.036 | p = 0.84 | p = 0.42 | ||
Nadir CD4 T cell count (cell/ml) | n = 15 | n = 15 | n = 14 | n = 14 | n = 14 | n = 14 | |
r = − 0.43 | r = 0.16 | r = − 0.19 | r = − 0.29 | r = − 0.27 | r = − 0.22 | ||
p = 0.090 | p = 0.66 | p = 0.58 | p = 0.19 | p = 0.44 | p = 0.49 | ||
CD4/CD8 T cell ratio | n = 15 | n = 14 | n = 15 | n = 15 | n = 14 | n = 15 | |
r = − 0.53 | r = 0 | r = − 0.17 | r = − 0.27 | r = − 0.059 | r = − 0.16 | ||
p = 0.022 | p = 0.50 | p = 0.55 | p = 0.15 | p = 0.84 | p = 0.55 | ||
Viral Load (copies/ml) | n = 14 | n = 14 | n = 14 | n = 14 | n = 14 | n = 14 | |
r = 0.42 | r = 0.0083 | r = − 0.23 | r = 0.17 | r = − 0.033 | r = − 0.14 | ||
p = 0.14 | r = 0.98 | p = 0.43 | p = 0.27 | p = 0.92 | p = 0.63 | ||