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Fig. 14 | Journal of Biomedical Science

Fig. 14

From: The role of the bacterial protease Prc in the uropathogenesis of extraintestinal pathogenic Escherichia coli

Fig. 14

The model describing how deficiency in the Prc protease leads to defective bacterial motility in E. coli. Prc protease deficiency interferes with proteolytic regulation of its substrates in the bacterial envelope, leading to uncontrolled levels of Prc substrates, such as Spr. The accumulation of the substrates may alter the OMP profile, leading to compromised OM integrity and disturbing peptidoglycan biogenesis. The resulting disturbance in the envelope triggers activation of the σE or RcsCDB extracytoplasmic stress response systems. The activated σE and RcsCDB systems decrease flagellar biosynthesis and thus bacterial motility

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