Fig. 5
From: Translation control of Enterovirus A71 gene expression
The regulatory roles of miR-141 and vsRNA in EV-A71 translation. EV-A71 infection upregulates miR-141 expression through activation of EGR1 transcription factor. miR-141 targets the 3′ UTR of eIF4E mRNA to inhibit eIF4E protein expression, and thus inhibits cap-dependent translation of host mRNAs. After EV-A71 infection, Dicer cleaves EV-A71 IRES to produce vsRNAs, which repress IRES-mediated translation and virus replication. vsRNAs may alter the binding of AUF1, Ago2, and/or HuR to IRES, and thus downregulate or upregulate viral IRES-mediated translation