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Table 1 Cellular proteins involved in the regulation of enterovirus A71 mRNA translation

From: Translation control of Enterovirus A71 gene expression

Host factorsThe effects of host proteins on EV-A71 translationRefs
hnRNP A1/A2hnRNP A1 promotes IRES-mediated translation after EV-A71 infection and its function in translation can be replaced by hnRNP A2.[31,32,33]
PTB1Nuclear PTB1 is transferred to the cytoplasm and interacts with EV-A71 IRES domain VI to promote viral mRNA translation.[34,35,36,37]
PCBP1/2PCBP1/2 also function as ITAFs by interaction with domain IV of type 1 IRES to promote viral translation.[48,49,50]
Sam68Sam68 binds specifically to EV-A71 IRES domains IV and V and acts as an ITAF to upregulate viral translation.[41]
DDX3DDX3 may indirectly binds to the domain VI of EV-A71 IRES and then unwind the secondary structure to facilitate ribosome entry.[42]
HuRHuR binds to the domain II of EV-A71 IRES by viral small RNA and promotes viral IRES-mediated translation.[43]
Ago2Ago2 binds to the domain II of EV-A71 IRES by viral small RNA and promotes viral IRES-mediated translation.[43]
FBP1FBP1 binds to the EV-A71 5′ UTR linker region to promote IRES-mediated translation and virus production. FBP1 activates viral IRES activity by competing with FBP2.[44]
FBP2FBP2 binds to the IRES of EV-A71 and acts as a negative regulator of viral IRES-mediated translation.[45]
AUF1AUF1 binds to the domain II of EV-A71 IRES by viral small RNA and represses viral IRES-mediated translation.[46, 47]
SRp20SRp20 interacts with PCBP2 and functions to promote type 1 IRES-mediated translation.[51, 52]
Hsp27Hsp27 activates viral protease 2Apro to cleave host eIF4G protein, and thus inhibits host cap-dependent translation and enhances viral IRES-mediated translation.[53]
Hsc 70Hsc70 enhances viral 2Apro activity to cleave host eIF4G protein, and thus inhibits host cap-dependent translation and enhances viral IRES-mediated translation.[54]
MINKEV-A71 infection induces the phosphorylation of MINK and then stimulates the transfer of hnRNP A1 into the cytoplasm where it binds to the viral IRES and promotes viral IRES-mediated translation.[55]