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Fig. 1 | Journal of Biomedical Science

Fig. 1

From: Clinical trials of new drugs for Alzheimer disease

Fig. 1

On the basis of the amyloid hypothesis, the consequent events of pathophysiology and clinical course are amyloid accumulation, neuroinflammation, tau accumulation, brain metabolism dysfunction, brain atrophy, cognitive decline (from mild cognitive impairment to dementia), and dementia symptom development. New drugs should target at least one of these events

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