Therapeutic applications of nucleic acid aptamers in microbial infections

Table 2 A summary of several aptamers developed for the treatment of viral infections by SELEX method

Organism	Type of aptamer	Target	Aptamer therapeutic effect	Ref
HBV	DNA	Core protein	-Prevent the assembly of the nucleocapsid -function by suppressing HBV replication	[82]
HCV	DNA	Envelope Protein	-Inhibition of virus binding to host cells	[90]
Influenza A virus	DNA	Hemagglutinin protein	-Blocking the binding of virus to target cell receptors -prevention of the virus invasion into the host cells	[83]
Ebola Virus	RNA	VP35	-Disrupt the eVP35− NP interaction	[91]
HIV-1	RNA	gag protein	-Inhibit HIV-1 replication	[92]
HSV-1	RNA	gD protein	-Blocking the gD functions	[85]
Vaccinia virus	DNA	Hemagglutinin protein	-Recognize proteins expressed on the surface of VV- infected cells	[93]
Influenza B Virus	RNA	Hemagglutinin protein	-Inhibited HA-mediated membrane fusion	[94]
SCV	RNA	nsP10	-Inhibit double-stranded DNA unwinding activity of the helicase	[89]
Rabies virus	DNA	Blocking the interaction between rabies virus and permissive host cell receptors	-Reduced viral replication in an in vitro infection model	[84]

ISSN: 1423-0127