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Table 2 A summary of several aptamers developed for the treatment of viral infections by SELEX method

From: Therapeutic applications of nucleic acid aptamers in microbial infections

Organism Type of aptamer Target Aptamer therapeutic effect Ref
HBV DNA Core protein -Prevent the assembly of the nucleocapsid
-function by suppressing HBV replication
HCV DNA Envelope Protein -Inhibition of virus binding to host cells [90]
Influenza A virus DNA Hemagglutinin protein -Blocking the binding of
virus to target cell receptors
-prevention of the virus invasion into the host cells
Ebola Virus RNA VP35 -Disrupt the eVP35− NP interaction [91]
HIV-1 RNA gag protein -Inhibit HIV-1 replication [92]
HSV-1 RNA gD protein -Blocking the gD functions [85]
Vaccinia virus DNA Hemagglutinin protein -Recognize proteins
expressed on the surface of VV- infected cells
Influenza B Virus RNA Hemagglutinin protein -Inhibited HA-mediated membrane fusion [94]
SCV RNA nsP10 -Inhibit double-stranded DNA unwinding activity of the helicase [89]
Rabies virus DNA Blocking the interaction
between rabies virus and permissive host cell receptors
-Reduced viral replication in an in vitro infection model [84]
  1. VP35 viral protein 35, NP nucleoprotein, nsP10 NTPase/Helicase