Table 3 A summary of several aptamers developed for the treatment of parasitic infections by SELEX method
From: Therapeutic applications of nucleic acid aptamers in microbial infections
Organism | Type of aptamer | Target | Aptamer therapeutic effect | Ref |
|---|---|---|---|---|
E. histolytica | RNA | Polyadenylation factor EhCFIm25 | Inhibited parasite proliferation and led to cell death | [102] |
L. infantum | DNA | rLiPABP | Affecting the physiological role of PABP | [101] |
P. falciparum | RNA | EMP1 | Disruption and sequestration of parasites Reduced rosette formation | [99] |
T. cruzi | RNA | Cell adhesion | Inhibit cell invasion | [98] |
T. brucei | RNA | VSG proteins | Directing antibodies to the surface of the parasite | [103] |