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Fig. 5 | Journal of Biomedical Science

Fig. 5

From: Dopamine D3 receptor and GSK3β signaling mediate deficits in novel object recognition memory within dopamine transporter knockdown mice

Fig. 5

Effects of knocking down GSK3α or GSK3β on the NOR task in mice. a Stereotaxic coordinates for lentiviral injections. b Timeline of the surgery and behavioral analysis. c Effect of knocking down GSK3α or GSK3β on exploring a novel and a familiar objects in the retention trial of the NOR task. Data are shown as mean ± SEM (n = 6 per group). ***p < 0.001. d Effect of knocking down GSK3α or GSK3β on DI. Data are shown as mean ± SEM (n = 6 per group). *p < 0.05, compared with shLacZ group. e Knockdown efficiency of shGSK3α and f shGSK3β. Data are shown as mean ± SEM (n = 6 per group). **p < 0.01, ***p < 0.001 compared to the shLacZ group

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