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Table 1 Examples of miRNAs involved in DENV infection

From: Role of microRNAs in antiviral responses to dengue infection

microRNAVirus-typesHost systemEffectTargetReference
miR-548 g-3pDENV-1 (strain Hawaii), DENV-2 (strain New Guinea C), DENV-3 (Philippine H87 Strain) and DENV-4 (GZ/ 9809/2012)U937AntiviralDirect: viral 5′ UTR[71]
miR-133aDENV-1, DENV-2 (strain New Guinea C) and DENV-4VeroAntiviralDirect: viral 3′ UTR[72]
miR-484DENV-1, DENV-2 (strain New Guinea C) and DENV-4VeroAntiviralDirect: viral 3′ UTR[73]
miR-744DENV-1, DENV-2 (strain New Guinea C) and DENV-4VeroAntiviralDirect: viral 3′ UTR[73]
miR-252DENV-2 (strain New Guinea C)C6/36AntiviralDirect: viral gene E[74]
Let-7cDENV-2 (strain New Guinea C) and DENV4 (strain V3361–1956)Huh7, U937-DC-SIGNAntiviralIndirect: BACH1[75]
miR-30e*DENV-1 (strain Hawaii), DENV-2 (strain New Guinea C) and DENV-3 (strain H241)HeLa, U937 and PBMCsAntiviralIndirect: IκBα[76]
miR-34 family (miR-34a, miR-34c, miR-449a and miR-449b)DENV-2 (strain New Guinea C)HeLaAntiviralIndirect: Wnt pathway[56]
miR-223DENV-2 (strain TR1751)EAhy926 cellsAntiviralIndirect: STMN1 mRNA[77]
miR-3614-5pDENV-2 (strain 16,681)Primary human macrophageAntiviralIndirect: ADAR1 mRNA[78]
miR-146aDENV-2 (strain New Guinea C)Primary human monocytes and THPI cellsProviralIndirect: TRAF6[79]
miR-21DENV-2 (strain 16,681)HepG2ProviralDirect: NS1 sequence[80]
mir-150DENV-2 (strain New Guinea C)PBMCs from DHF patientsBiomarker for severe diseaseDownregulated SOCS1 resulting in lower IFN-γ production[81]
  1. Abbreviations: DENV Dengue virus, UTR Untranslated region, BACH1 Basic leucine zipper transcription factor 1, STMN1 Stathmin 1, ADAR1 Adenosine deaminase acting on RNA 1, NS1 Non-structural protein 1, SOCS1 Suppressor of cytokine signaling, IFN Interferon, TRAF6 Tumor necrosis factor receptor (TNFR)-associated factor 6