Summary (with examples) of the multifaceted roles of lncRNAs in the cell. a The X chromosome-derived lncRNA Firre associates with HnRNPU to establish inter-chromosome architecture. bCCAT1-L generated from upstream of MYC loci promotes MYC expression via CTCF-mediated looping. c Paraspeckle formation is regulated by interactions between NEAT1_2 and RBPs. d X chromosome inactivation is accomplished by coordination between Xist-PRC2-mediated deposition of H3K27me3 and Xist-SMRT/SHARP/HDAC-mediated deacetylation of H3ac. e Facilitation of RNA splicing by Pnky/PTBP1 and Malat1/RBPs complexes. fBACE1-AS associates with BACE1 mRNA via the open reading frame to stabilize BACE1 mRNA. gH19 lncRNA sequesters let-7 miRNA to prevent let-7-mediated gene suppression. h Antisense Uchl1 promotes but lincRNA-p21 inhibits the translation process.