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Fig. 2 | Journal of Biomedical Science

Fig. 2

From: Functional Roles of Long Non-coding RNAs in Motor Neuron Development and Disease

Fig. 2

Schematic illustration of spinal motor neuron development. a Notochord- and floor plate-derived sonic hedgehog protein (Shh), and roof plate-generated wingless/integrated (WNT) protein and bone morphogenetic (BMP) protein, as well as retinoic acid (RA) diffusing from the paraxial mesoderm, pattern the identities of spinal neurons by inducing cross-repressive transcription factors along the dorso-ventral axis (pd1~6, p0, p1, p2, pMN, and p3). Motor neuron progenitors (pMNs) are generated by co-expression of Olig2, Nkx6.1 and Nkx6.2. After cell cycle exit, pMNs give rise to generic MNs by concomitantly expressing Isl1, Lhx3 and Mnx1. Along the rostro-caudal axis, Hox6/Hoxc9/Hox10 respond to RA and fibroblast growth factor (FGF) to pattern the brachial, thoracic and lumbar segments, respectively. b In the Hox6on segment, the interaction between PRC2-Jarid2 complex and a Isl1/Lhx3 induced lncRNA Meg3 perpetuates the brachial Hoxa5on MN by repressing caudal Hoxc8 and alternative progenitor genes Irx3 and Pax6 via the maintenance of H3K27me3 epigenetic landscape in these genes. Yet the detailed mechanism how Meg3 targets to these selective genes still needs to be illustrated.

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