From: Functional Roles of Long Non-coding RNAs in Motor Neuron Development and Disease
LncRNA | Disease | Proposed function | Organism/cell models | Reference |
---|---|---|---|---|
ATXN2-AS | ALS | (CUG)n repeat expansions induce neurotoxicity. | SK-N-MC neuroblastoma cells and lymphoblastoid cell lines from ALS patients | [75] |
C9ORF72 antisense RNA | ALS | Forms RNA foci and repeat-associated non-AUG (RAN) translation generates dipeptides to cause neurotoxicity. | Drosophila, Zebrafish/Neuro-2a, mouse primary cortical and motor neurons | |
NEAT1 | ALS | Facilitates paraspeckle formation. High levels of NEAT1 trigger neurotoxicity. | Mouse/NSC-34 MN-like cells | |
SMN-AS1 | SMA | Recruits PRC2 complex to suppress the SMN gene. | Mouse/human SMA-iPSC-derived MNs, SMNΔ7 mouse cortical neurons |