Skip to main content
Fig. 2 | Journal of Biomedical Science

Fig. 2

From: Treatment of rats with spinal cord injury using human bone marrow-derived stromal cells prepared by negative selection

Fig. 2

Health status after SCI. No adverse events were attributed to bmSC treatment. a Changes of body weight following SCI: Initially, stem cell-treated rats lost more body weight while at a later stage (starting at 14 dpo) they gained more weight compared to MP- and vehicle-treated animals. Data were normalized to the body weight before surgery (mean +/− SEM; two factor ANOVA, post hoc Tukey test, * p < 0.05, ** p < 0.01). b Recovery of the spontaneous micturition reflex: Displayed is the time after SCI [days] that passed until the animals no longer required manual voiding of the bladder by the experimenter (median, 25%/95% and range). There were no significant differences between treatment groups (H-test). c Testing of mechanical nociception (von Frey, reduced threshold of paw withdrawal response) at nine weeks after SCI showed no hyperalgesia/allodynia in bmSC implanted animals, while this occurred in 1/5 rats treated with MP and 3/9 rats that had received NaCl injections. Treatments following SCI are designated as: control - injections of 0.8% saline solution; MP - of methyl prednisolone; bmSC - of human bone marrow-derived stem cells

Back to article page