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Fig. 7 | Journal of Biomedical Science

Fig. 7

From: Chemoresistant ovarian cancer enhances its migration abilities by increasing store-operated Ca2+ entry-mediated turnover of focal adhesions

Fig. 7

SOCE inhibitors decrease migration ability of chemoresistant IGROV1 cells in wound healing assay. In vitro wound healing migration assay was performed to evaluate the effect of SOCE inhibitors (2 μΜ SKF-96365, 10 μΜ YM-58483, 0.1 μM 2-APB) on chemoresistant IGROV1 (CP, SRT) cells. a, c (a) IGROV1-CP and (c) IGROV1-SRT cells were seeded into silicon inserts with 10% FBS medium. Following cell adhesion, inserts were removed and incubated for 36 h. Phase images were captured every 12 h and wound spaces were analyzed using ImageJ. b, d Cellular migratory ability is presented as the percentages of wound closure. Each bar represents mean ± SEM from three independent experiments. *: significant difference between cells treated with SOCE inhibitors and DMSO control (Control). *: p < 0.05; **: p < 0.01 by Student’s t-test

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