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Fig. 3 | Journal of Biomedical Science

Fig. 3

From: Epigenetic regulation of epithelial-mesenchymal transition: focusing on hypoxia and TGF-β signaling

Fig. 3

Different epigenetic signaling pathways regulated during TGF-β-induced EMT. a The regulation of EMT-Ms (mainly E-cadherin promoter) is shown through different epigenetic regulators. b The regulation of EMT-TFs (mainly Snail and ZEB2 promoters) by TGF-β is shown through different epigenetic regulators. Please notice that only the Smad3-SETDB1 pathway is shown in the repression of Snail promoter, in which SETDB1 expression is repressed by TGF-β. The opposite pathway of Smad3-CBP/p300 association triggered by TGF-β to activate Snail promoter is described in the text but not included in this panel

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