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Fig. 4 | Journal of Biomedical Science

Fig. 4

From: Clinical-grade cryopreserved doxorubicin-loaded platelets: role of cancer cells and platelet extracellular vesicles activation loop

Fig. 4

MDA-MB-231 cells trigger PLT activation and thrombin generation. (a) MP-TF activity and (b) thrombin generation induced by cryopreserved PLT with MDA-MB-231 cells, MDA-MB-231 cells, cryopreserved PLT and PPP, as measured by MP-TF activity assay and thrombin generation assay, respectively. (c) Schematic representation of the mechanisms through thrombin induced activation of cryopreserved DOX-loaded PLT compared to PLT to form peudopodia (white arrow) and release of PEV (red arrow). (** p < 0.01, **** p < 0.0001. Abbreviations: PC: platelet concentrate, PLT: platelet, DOX: doxorubicin, FPD: cryopreserved DOX-loaded PLT, PEV: PLT-derived extracellular vesicle. PPP: PLT poor plasma

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