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Table 2 ncRNAs and related processes in Parkinson’s disease

From: Functional roles and networks of non-coding RNAs in the pathogenesis of neurodegenerative diseases

  Name up/down regulation Stimulation Description Model Ref
lncRNAs HOTAIR up MPTP correlated with LRRK2 upregulation and activating caspase 3 dependent apoptosis mouse model [58]
HOTAIR up MPTP blocking miR-126-5p/RAB3IP interaction and promoting DA neurona death mouse model [59]
NEAT1 up MPTP Positively correlated with treated MPTP concentration. NEAT1 upregulation promotes Bax/BCl ratio, caspase 3 activity and α-synuclein expression. NEAT1 knokdown promotes cell viability and supresses apotosis. mice, cell line [60]
NEAT1 up MPTP NEAT1 correlated with neuroinflammation after MPP+ treatment (IL-1b, IL-6 and TNF-a upregulation). NEAT1 serves as miR-124 decoy and promotes cell death and apoptosis. mice, cell line [61]
NEAT1 up MPTP NEAT1 promotes PINK1 protein stability via preventing degredation. NEAT1 positively correlated to LC3-II/LC3-I level and promotes autophogy. mice, cell line [62]
NORAD down MPP+ NORAD protects cell against MPP+ induced cytotixity inclduing caspase3/7, ROS and LDH activity with unknown mechanism. cell line [12]
p21 up MPTP p21 positvely regulates TRPM2 expression by targeting miR-625. p21 serves as a miR-625 decoy and inhibits TRPM2 function in causing neuronal injury. cell line [63]
p21 up MPTP p21 is miR-1277-5p decoy and prevents miR-1277-5p directly targeting a-synuclein expression. P21/miR-1277-5p/a-synuclein axis leads to apoptosis in MPP+ induced PD models. mouse [64]
SNHG1 up MPTP SNHG-1 is a miRNA sponge of miR-221/222 and prevents p27 targeting and activation of mTOR pathway. Downregulation of SNHG1 attenuated MPP+ induced decreases in LC3-II (an autophagic marker) levels and cytotoxicity through the miR-221/222/p27/mTOR pathway. cell line [65]
SNHG1 down   miR-15 decoy and inhibit miR-15 function cell line [66]
SNHG1 up LPS Upregulation of SNHG1 promotes neuroinflammation in BV2 microglia of PD models. SNHG-1 functioned as a competing endogenous RNA for miR-7 to regulate NLRP3 expression leading to the activation of NLRP3 inflammasome. mice, cell line [67]
U1 splicesomeal lncRNA, RP11-462G22.1 up   Upregulated in patiensts’ leukocyte, amygdala and substantia-nigra. Computational prediction shows miRNA decoy, and exhibit a more complex secondary stem-loop structure. Potentially as decoy of 21 different miRNAs (potential ceRNA). PD patient tissue [68]
tRNA-derived fragment    A list of tRNA-derived fragment are consistently founded in pateits’ CSF, serum and cortex. The tRNA-derived fragment are the biomarkers of PD. PD CSF, cortex, serum [69]
NATs UCHL1-AS   MPTP UCHL1-AS is an antisense to the mouse ubiquitin carboxy terminal hydrolase L1 and activates transcription of UCHL1. UCHL1 is under the regulation of Nurr1(a major transcription factor) in dopaminergic differentiation, maintenance and related to cellular stress in the brain. mouse, PD patient [25]
GDNF-AS   6-OHDA GDNF-AS is coded for GDNF and enable to promote GDNF expression by 2 fold. GDNF-AS delivery by Adeno-associated virus was able to ameliorate motor deficits and neurodegeneration of DA neurons in a PD mouse models lesioned by6-OHDA treatment. mouse [70]
circRNAs circSNCA up MMP+ circSNCA serve as a miR-7 sponge and prevents miR-7 targeting SNCA expression. Increased SNCA induce pro-apoptotic genes (CASP3, BAX, PTEN and P53). Knockdown of circSNCA shows the anti-apoptotic gene (BCL2) expression and prevents apoptosis. cell line [12]
miRNAs miR-126 up 6-OHDA miR-126 directly targets p85b, IRS-1, SPRED1 and impaires IGF-1/PI3K/AKT signaling. miR-126 leads to 6-OHDA induced neurotoxity. cell line [71]
  miR-126-5p down   miR-126-5p increase cell proliferation and reduce apotosis via targeting RAB3IP cell line [59]
  miR-133a/b    miR-133 targeted PITX3 mutations/polymorphisms are not related to PD risk. human genome sequence [72]
  miR-133b down   miR-133b targets RhoA (inhibitor of axonal growth) and indcue axonal outgrowth. miR-133b inhibits a-synuclein expression, Bcl/bax ratio and activates pAkt for neuronal survival. cell line [72]
  miR-153 down MPP+ miR-153 reduces p38 activation and prevents neuro-inflammation induced apoptosis mouse primary cortical neuron [73]
  miR-16-1 up   miR-16-1 targets Hsp70 3’UTR and negatively regulate a-synuclein aggregation SH-SY5Y [74]
  miR-183 up   miR-183 promotes apotosis of substantia nigra neuron by inhibit the expression of OSMR. cell line [75]
  miR-205 down   mir-205 suppresses the expression of LRRK2 protein through a conserved-binding site at the 3′-UTR of LRRK2 gene and promotes neurite outgrowth. PD brain section [76]
  miR-22 down 6-OHDA miR-22 overexpression downregulates the level of TRPM7, exhibited neuroprotective and reversal effect on the 6-OHDA-induced PCL2 cell growth and apotosis. cell line [77]
  miR-221 down MPP+ DJ-1 may increase miR-221 expression through the MAPK/ERK pathway, leading the repression of apototic molecules BIM. cell line [70]
  miR-27a/b down CCCP miR-27a/b suppress PINK1 expression through targeting 3′ UTR. Donwregulated PINK1 by miR-27a/b prevents its aggregation upon mitochondria damage and inhibits lysosomal degradation of damaged mitochondria. cell line [21]
  miR-342-3p up MPTP miR-342-3p directly targets PAK1(p21-activated kinase 1) in Wnt signallg pathway. miR-342-3p also reduce expression of GLT-1, GLAST, and leads to reduce TH expression and the related apoptosis. mouse [6]
  miR-34b/c down   miR-34b/c targets α-synuclein 3’UTR and reduces expression. In SNP of α-synuclein in Parkinson’s disease, failed miR-34b/c targeting causes α-synuclein expression and the related PD pathogenesis. cell line [78]
  miR-494 up MPTP miR-494 directly binds to 3′-UTR of DJ-1 transcript and inversely regulates the expression of DJ-1 which compromise anti-oxidative defence of cell. mice [79]
  miR-7 down   miR-7 represses a-synuclein protein level through binding 3′ UTR of A4 component of amyloid precursor (SCNA; gene name of a-synuclein) and protects cell against oxidative stress. PD brain section [12]
  miR-7/miR-153 down MPP+ Both miR-7 and miR-153 activate p70S6K/pS6RP/SAPK/JNK mediated mTOR pathway. mouse primary cortical neuron [73]
  miR-96 up MPTP CACNG5 is the target gene of miR-96. CACNG5 and BCL2 inhibition are linked to the activation of iNOS and apotosis. mice [80]