Skip to main content

Table 3 ncRNAs and related processes in Alzheimer’s disease

From: Functional roles and networks of non-coding RNAs in the pathogenesis of neurodegenerative diseases

  Name up/down regulation genetic mutation Description Model Ref
LncRNAs BC1 up Tg2576-APPswe Induces APP mRNA translation via association with fragile X syndrome protein (FMRP). Induces Aβ peptides accumulation and affects spatial learning and memory impairments of mice. mouse [83]
  BC200 up   Regulate cell vialbility via directly targeting BACE1 mRNA expression. BC200 increases BACE1 expression and enhances Aβ1–42 expressioin. AD brain section [8486]
  LncRNA -17A up Aβ1–42 treatment Upregulates autophagy, deactivates GABAB signaling and induces neurodegeneration. neuroblastoma [87]
  LncRNA -17A up Inducing inflammation response Impaires GABAB signaling through mediating receptor isoform switch via altering alternative splcing, and further induce Aβ secretion and increment of Aβ42/40 ratio. AD brain section, SH-SY5Y cells [88]
  MEG3 up microinjection of Aβ25–35 Inhibiting the PI3K/Akt signaling pathway and apoptosis of hippocampal neurons, decreased Aβ expression, inhibited oxidative stress injury and inflammatory injury. rat [89]
  MIAT down APPswe/PSEN1ΔE9 Regulates amyloid clearance via regulating low-density lipoprotein receptor related protein 1 (LRP1) expression and miR-150-5p/VEGF mediated fibrillogenesis; Increased Aβ40 and Aβ42 levels and neuronal loss; Decreased brain microvessel number and the expression of tight junction proteins. mouse [90]
  NDM29 up Induces APP synthesis and promotes cleavage activity of BACE1 and γ-secretase. Increase Aβ secretion and increment of Aβ42/40 ratio. AD brain section, mouse neuroblastoma [88]
  NEAT1 up Aβ1–42 treatment Mediates Aβ and pTau induced neuronal death via acting as miR-107 decoy. human cell line [91]
  NEAT1 up Mediates Aβ secretion and pTau via regulating miR-124/BACE1 regulation. mouse model [92]
  NEAT1 up Negetively regulating CDK5R1 mRNA level through positively regulating miR-15/107. AD brain [93]
  P3Alu/SINE up in RPE Neurodegeneration via P3Alu-induced inflammasomes (in RPE; still a hypothesis in neurons) AD brain section, mouse model [94]
NATs BACE1-AS up APP-KM670/ 671NL and V717F Stabilizes BACE1 mRNA and prevents miR-485-5p targeting on BACE1 mRNA. Increased Aβ42 is identified in the models. AD brain section, mouse [95, 96]
  BDNF-AS up In epigenetic level, promots BDNF depletion. mouse model, HEK293T [33]
  EBF3-AS up APPswe/PSEN1ΔE9, Aβ25–35 treated cell Reduces EBF3 (early B cell factor 3) expression and promots cell death. mouse model, cell [97]
  SORL1-AS(51A) up SORL1-AS is the antisense orientation in intron 1 of the SORL1 gene and decrease SORL expression via altering splicing. SORL1-AS overexpression results in impaired processing of APP and increased Aβ formation. AD brain section [98]
  SOX21-AS1 up Aβ1–40 treatment Reducing Frizzled 3/5 (FZD3/5) mediated Wnt signaling pathwa and trigged oxidative stree and cell death in hippocampal neurons. mouse model [99]
  NAT-RAd18 up Aβ1–40 treatment Promotes DNA damage via reducing Rad18 expresion, and leads to cell death. Rat cortical neurons [100]
  LRP1-AS up Disrupts LRP1 mediated Aβ clarance via directly binding to high-mobility group box 2 (Hmgb2) and blocking the Srebp1a-dependent transcription of LRP1. Promotes APP endocytic trafficking, increases Aβ formation and decreases Aβ clearance. AD brain section, Hmgb2 KO mice and mouse RAW264.7 cell line [101, 102]
  EBF3-AS, HAO2-AS, AD-lic1, AD-linc2 up Promoting neuron apoptosis. AD brain section [103]
microRNAs let-7b up Activating RNA-sensing Toll-like receptor 7 and neuronal death. AD CSF, mouse model, macrophages [104]
  miR-106b up Tg-APPswe/PSΔE9 Regulate TGF-β signaling pathways and reduce phosphprylation of Smad2/3 and smad6/7 for promoting neurodegenration. mouse models [105]
  miR-106b down Regulates tau phosphoryation via targeting Fyn (tyrosine kinase) and increase pTau. AD brain section, human cell line [106]
  miR-128 up 3xTg-AD Reducing APP expression, Aβ production and inflammatory response via tardeting peroxisome proliferator-activated receptor gamma (PPARγ) expression. mouse model [107]
  miR-34a, mIr132/212 down 3x Tg-AD (PSEN1(PS1M146V), APP (APPSwe) and Tau (P301L) Correlated with Aβ production via targeting Sirt. Sirt can regulate Aβ production. mouse model [108, 109]
  miR-132/212 down 3x Tg-AD (PSEN1(PS1M146V), APP (APPSwe) and Tau (P301L) Regulating Tau expression via direct interaction and association with GSK-3β and PP2B mediated tau phosphorylation. AD brain section, mouse model, mouse neuroblastoma [110]
  miR-142a-5p, miR-146a-5p, miR-155-5p, miR-455-5p up APPswe/PS1L166P, THY-Tau22 May be part of a protective response in AD. AD brain section, mouse model [110]
  miR-15/107 down Increase expression of CDK5R1/p35 and consequently enhance CDK5 activity. miR-15/107 also modulates BACE1 expression and increase APP protein expresin and pTau formation. AD brain section, human cell lines [111, 112]
  miR-16 down   Attenuate Aβ mediated neurotoxicity via reducing BACE1 expression. post morten tissue [113]
  miR-200b/c up Aβ treatment/ Tg2576 transgenic mice miR-200b/c inhibits S6K1-dependent phosphorylation of IRS-1, suppresse IRS-1pSer signaling pathway and cause insulin resistance in the brain. Aβ secretion is corelated in the models. mouse model, mouse cell lines [114]
  miR-25 up Aβ1–42 induction Downregulating KLF2 via Nrf2 signaling pathway to suppress proliferation and promot apoptosis. mouse model [115]
  miR-29a/b-1 down Decreases BACE1 expression. AD brain section [116]
  miR-29c down Regulating the expression of BACE1 by directly targeting its 3’UTR and promoting cell proliferation via PKA signaling. Increasing BACE1 level via PKA/CREB signaling pathway. Peripheral blood of AD pateints, SAMP mouse model [117]
  miR-33 deletion miR-33(−/−); APPswe/PSEN1ΔE9, Increasing ATP-binding cassette transporter A1 (ABCA1) expression, ApoE lipidation, and decreaseing Aβ level. mouse and human neural cells [118]
  miR-34a up APPswe/PSEN1ΔE9 Regulating γ-secretase activity, BACE1 expression and lead to increasing Aβ level. Interacting with the 3′-UTR of bcl2 mRNA and inhibiting bcl2 translation, and increasing caspase 3 activity. mouse model [119, 120]
  miR-485-5p down miR-485-5p is corelated to BACE1 upregulation. The expression of two competitively regulatory RNAs, miR-485-5p and BACE1-AS, are dysregulated. AD brain section [96]
  miR-873-5p down Aβ1–42 induction Preveting apoptosis via targeting Heme oxygenase 1 (HMOX1) expression level. mouse model, rat cell line [121]
  miR-338-5p down 5XFAD transgenic (TG) mice Mediaing amyloid formation via targeting BACE1; associtaed with NF-kB signaling pathway activation. Doenregulated miR-338-5p increases BACE1 expression, Aβ formation, and neuroinflammation. AD brain section, mouse [122]