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Fig. 4 | Journal of Biomedical Science

Fig. 4

From: Functions and properties of nuclear lncRNAs—from systematically mapping the interactomes of lncRNAs

Fig. 4

Mapping RNA-protein interactions. In CLIP-seq, iCLIP-seq, and PAR-CLIP-seq, RNA associated chromatin complexes are crosslinked by UV light, pulled down using antibodies against a specific protein of interest, and the captured RNA are sequenced. In PAR-MS, ChIRP-MS, and iDRiP-MS, RNA-protein complexes crosslinked by UV light or formaldehyde, captured by antisense oligos, and the pulled-down proteins are identified by mass spectrometry. RBR-ID utilizes protein-RNA photocrosslinking and quantitative MS to identify all proteins that interact with RNA

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