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Fig. 5 | Journal of Biomedical Science

Fig. 5

From: Functions and properties of nuclear lncRNAs—from systematically mapping the interactomes of lncRNAs

Fig. 5

Profiling RNA structure and RNA-RNA interactions. FragSeq, PARS and SHAPE-seq reveal in vitro RNA structures by nuclease or chemical probing. DMS-seq, icSHAPE-seq, and COMRADES map in vivo RNA structures by modifying RNA with chemicals. CLASH and hiCLIP can identify RNA-RNA duplexes bound by a specific protein. MARIO, PARIS, and SPLASH map all RNA-RNA interactions by introducing a linker to ligate RNA and RNA

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