Fig. 1

Abnormal lung function in CPEB2-KO mice. a Whole-body plethysmographic recording of CPEB2-WT (CP2WT) and CPEB2-KO (CP2KO) mice at age 2–3 months (n = 7 per group). Representative recorded traces and results of respiratory frequency, normalized tidal volume (Vt/ body weight), peak inspiratory and expiratory flow (PIF and PEF), inspiratory and expiratory time (Ti and Te). b Values of enhanced pause (Penh) indicating airway reactivity determined by whole body plethysmography in adult CP2WT and CP2KO mice (n = 4 per group) with increasing doses of inhaled methacholine (Mch). c Airway resistance, pulmonary elastance and dynamic compliance in adult tracheotomized mice (WT/KO = 4/5) challenged with increasing doses of Mch determined by an invasive forced oscillatory system. Data are mean ± s.e.m., *P < 0.05, **P < 0.01 and ***P < 0.001, by two-way ANOVA and Bonferroni post-hoc test